摘要
近年来,随着对肿瘤生物学研究的不断深入,人们对复杂的肿瘤代谢重编程更新、更全面的认识。葡萄糖转运蛋白1(glucose transport protein-1,GLUT-1)在不同肿瘤细胞的质膜上有不同程度的过度表达,过表达的GLUT-1会使肿瘤细胞摄入更多的葡萄糖以重编程细胞的代谢模式,。同时,对肿瘤微环境的改变有着重要的影响。并且,在肿瘤中GLUT-1的调节是近年来关注的重点,目前,已报道的上游调控因子主要有PTEN基因编码的蛋白质(phosphatase and tension homolog deleted on chromosome ten,PTEN)、缺氧诱导因子(hypoxia inducible factor,HIF),GLUT-1还会通过影响p53和细胞致瘤基因(cellular-myelocytomatosis viral oncogene,c-Myc)通路等在肿瘤的发生与发展中发挥着重要的作用。本文主要综述GLUT-1的结构与功能、在肿瘤代谢重编程中通过转运不同底物对肿瘤的影响、GLUT-1的调节和目前针对GLUT-1的治疗等。同时,阐述了GLUT-1与肿瘤代谢重编程的研究现状,分析了当前存在的问题,旨在为抗肿瘤机制研究以及恶性肿瘤靶向治疗研究提供参考。
In recent years,with the deepening of tumor biology research,people have a newer and more comprehensive understanding of complex tumor metabolism reprogramming.The glucose transport protein-1(GLUT-1)is a glucose transporter widely expressed in the cell membranes of various tissues and represents unusual overexpression in the plasma membrane of virous cancer cell.GLUT-1 can transport mannose,galactose,glucosamine and ascorbic acid(AA).GLUT-1 is overexpressed in different degrees on the plasma membrane of different tumor cells.Overexpressed GLUT-1 will make tumor cells take in more glucose to reprogram the metabolic mode of cells,and at the same time,it influences the change of tumor microenvironment.And the regulation of GLUT-1 in tumors has been the focus of attention in recent years,and the upstream regulators that have been reported mainly include phosphatase and tension homolog deleted on chromosome ten(PTEN)and hypoxia inducible factor(HIF).GLUT-1 also plays an important role in tumorigenesis and development by influencing the p53 and cellular tumorigenic gene(c-Myc)pathways.The review introduces structure and function of GLUT-1,the effects of transporting different substrates in tumor metabolic reprogramming,the regulation of GLUT-1,and the current treatment of GLUT-1.Meanwhile,the review discusses mechanisms and development of the role of GLUT-1 in cancer metabolism reprogramming,and points out the existing problems to provide reference for the research of metabolism reprogramming and targeted therapy of malignant tumors.
作者
白紫元
张巧
杨哲
BAI Zi-Yuan;ZHANG Qiao;YANG Zhe(Department of Pathology,First Affiliated Hospital of Kunming Medical University,Kunming 650032,China;Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Kunming Medical University,Kunming 650500,China)
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2023年第11期1554-1561,共8页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家自然科学基金青年科学基金项目(No.8210114905,No.82203565,No.8210338,No.831960145)资助。
关键词
葡萄糖转运蛋白1
肿瘤代谢重编程
恶性肿瘤
glucose transport protein 1(GLUT-1)
tumor metabolism reprogramming
malignant tumors
