摘要
目的分析儿童先天性心脏病(CHD)的危险因素及其预后情况。方法选取175例CHD患儿作为观察组,另选取100例同期体检健康儿童作为对照组,比较2组受试儿童的性别和母亲孕早期情况(感染、发热、先兆流产、服用抗生素、被动吸烟、精神刺激、化学药品接触史)、高龄产妇、经产妇、不良妊娠史、孕期营养、定期产检、孕妇妊娠合并症、孕期居住地与交通主干道<50 m、父母吸烟史、父亲文化程度及CHD家族史;将有差异的指标纳入多元logistic回归,分析影响CHD的危险因素;CHD患儿介入封堵术治疗后随访6个月,观察患儿预后生存情况。结果母亲孕早期感染、服用抗生素、化学药品接触史、被动吸烟及孕期营养差、未定期产检、存在CHD家族史、孕期居住地离最近交通主干道距离<50 m是导致患儿CHD的独立危险因素(P<0.05);术后6个月随访均无患儿死亡。结论儿童CHD发生与早期感染等多种因素有关,应提高孕妇的定期产检意识。
Objective To analyze the risk factors and prognosis of congenital heart disease(CHD)in children.Methods A total of 175 children with CHD were selected as the observation group and 100 healthy children with concurrent physical examination were selected as the control group.The gender,mother early pregnancy situation(infection,fever,threatened abortion,antibiotics,passive smoking,mental stimulation,chemical contact history),advanced maternal age,menstrual maternal age,adverse pregnancy history,pregnancy nutrition,regular prenatal examination,maternal pregnancy complications,pregnancy residence,and main road<50 m,smoking history of parents'age,father's education,and family history of CHD of children in the two groups were compared.Differential indicators were included in the multiple logistic regression to analyze the risk factors affecting CHD.Children with CHD were followed up for 6 months after interventional occlusion treatment to observe the prognosis survival of children.Results Infection in early pregnancy,antibiotics,contact history of chemicals,passive smoking,poor nutrition during pregnancy,no regular birth examination,family history of CHD,and residence during pregnancy<50 m away from the nearest main road were independent risk factors for CHD in children(P<0.05).No children died at 6 months of postoperative follow-up.Conclusion The occurrence of CHD in children is related to many factors such as early infection,so the awareness of regular obstetric examination shall be improved.
作者
黄婷
殷杰
陈梅
HUANG Ting;YIN Jie;CHEN Mei(Department of Cardiovascular Medicine,Children's Hospital Affiliated to Nanjing Medical University,Nanjing 210008,Jiangsu,China)
出处
《贵州医科大学学报》
CAS
2023年第12期1521-1525,共5页
Journal of Guizhou Medical University
基金
国家自然科学基金(81478358)。
关键词
先天性心脏病
儿童
危险因素
预后
介入封堵术
随访
congenital heart disease
children
risk factors
prognosis
interventional closure
follow-up
