摘要
目的对比精神分裂症患者接受低频重复经颅磁刺激(rTMS)与无抽搐电休克(MECT)治疗的临床疗效。方法86例精神分裂症患者,按入院顺序编号后随机分为电休克组和磁刺激组,每组43例。电休克组采取MECT治疗,磁刺激组采取低频rTMS治疗。对比两组治疗前后阳性与阴性症状量表(PANSS)、重复性成套神经心理状态量表(RBANS)、社会功能缺陷筛选量表(SDSS)评分及不良反应发生情况。结果治疗后,两组阳性量表评分、阴性量表评分及总评分均较治疗前明显降低,差异具有统计学意义(P<0.05);两组阳性量表评分、阴性量表评分及总评分对比差异均无统计学意义(P>0.05)。治疗后,两组RBANS评分、SDSS评分均低于本组治疗前,且磁刺激组RBANS评分(248.47±20.31)分、SDSS评分(5.17±1.04)分低于电休克组的(307.53±13.89)、(9.34±1.72)分,差异具有统计学意义(P<0.05)。磁刺激组不良反应发生率为6.98%,低于电休克组的25.58%,差异具有统计学意义(P<0.05)。结论MECT与低频rTMS治疗精神分裂症均有满意疗效,但低频rTMS在认知功能及心理状态改善方面存在一定优势,且安全性更高,更具推广价值。
Objective To compare the clinical efficacy of low-frequency repetitive transcranial magnetic stimulation(rTMS)and modified electric convulsive therapy(MECT)in patients with schizophrenia.Methods A total of 86 patients with schizophrenia were randomly divided into an electroshock group and a magnetic stimulation group,with 43 cases in each group.The electroshock group was treated with MECT,and the magnetic stimulation group was treated with low-frequency rTMS.The scores of Positive and Negative Symptom Scale(PANSS),Repeatable Battery for the Assessment of Neuropsychological Status(RBANS),Social Dysfunction Screening Scale(SDSS)before and after treatment and adverse reactions were compared between the two groups.Results After treatment,the positive scale score,negative scale score and total score in both groups were significantly lower than those before treatment in this group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in positive scale score,negative scale score and total score between the two groups(P>0.05).After treatment,RBANS score and SDSS score in both groups were lower than those before treatment in this group;RBANS score of(248.47±20.31)points and SDSS score of(5.17±1.04)points in the magnetic stimulation group were lower than those of(307.53±13.89)and(9.34±1.72)points in the electroshock group;the difference were statistically significant(P<0.05).The incidence of adverse reactions in the magnetic stimulation group was 6.98%,which was lower than that of 25.58%in the electroshock group,and the difference was statistically significant(P<0.05).Conclusion Both MECT and low-frequency rTMS have satisfactory efficacy in the treatment of schizophrenia,but low-frequency rTMS has certain advantages in improving cognitive function and mental state,and has higher safety and promotion value.
作者
刘竞鸿
LIU Jing-hong(Department of Geriatric Psychiatry,Jilin Neuropsychiatric Hospital,Siping 136000,China)
出处
《中国现代药物应用》
2023年第23期42-45,共4页
Chinese Journal of Modern Drug Application
关键词
低频重复经颅磁刺激
无抽搐电休克
精神分裂症
临床疗效
Low-frequency repetitive transcranial magnetic stimulation
Modified electric convulsive therapy
Schizophrenia
Clinical efficacy
