摘要
目的分析临床治疗甲状腺功能亢进疾病采用甲巯咪唑、碘131联合治疗的效果与价值。方法随机选取2022年1月—2022年12月沭阳县中医院收治的100例甲状腺功能亢进患者作为研究对象,以随机数表法分为对照组和观察组,各50例。对照组单纯以药物甲巯咪唑治疗;观察组采取甲巯咪唑、碘131联合治疗,分别对两组患者治疗前后甲状腺功能指标、骨代谢指标进行检测,分析变化趋势及组间统计学差异。观察两组患者治疗后产生的不良反应表现,计算且比较总发生率。结果治疗前两组甲状腺功能亢进患者甲状腺功能指标、骨代谢指标组间比较,差异无统计学意义(P>0.05);治疗后观察组患者甲状腺测定结果FT3为(5.15±1.01)pmol/L、FT4为(15.35±3.02)pmol/L、TSH为(15.58±2.02)UIV/mL均明显低于对照组,差异有统计学意义(t=14.194、11.565、10.492,P<0.05);同时骨代谢指标低于对照组,差异有统计学意义(P<0.05)。两组患者用药后出现的不良反应表现类型及总发生率比较,差异无统计学意义(P>0.05)。结论临床治疗甲状腺功能亢进疾病可在甲巯咪唑基础上联用碘131,可有效降低甲状腺功能指标,改善骨代谢功能,且不增加不良反应,安全性理想。
Objective To analyze the effect and value of the combination of methimazole and iodine 131 in the clinical treatment of hyperthyroidism.Methods A total of 100 patients with hyperthyroidism who were admitted to Shuyang Hospital of Traditional Chinese Medicine from January 2022 to December 2022 were randomly selected as the research objects,and they were divided into the control group and observation group by random number table method,with 50 cases in each group.The control group was treated with methimazole only.The observation group was treated with methimazole and iodine 131.The thyroid function inde xes and bone metabolism indexes of the two groups were detected before and after treatment,and the change trend and statistical differences between the two groups were analyzed.The adverse reactions after treatment in two group were observed,and the total incidence was calculated and compared.Results Before treatment,there were no significant differences in thyroid function indexes and bone metabolism indexes between the two groups(P>0.05).After treatment,the thyroid test results of the observation group were FT3[(5.15±1.01)pmol/L],FT4[(15.35±3.02)pmol/L],TSH[(15.58±2.02)UIV/mL],which were significantly lower than those of the control group,and the differences were statistically significant(t=14.194,11.565,10.492,P<0.05).At the same time,the bone metabolism index was lower than that of the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the types and total incidence of adverse reactions between the two groups(P>0.05).Conclusion Clinical treatment of hyperthyroidism can be combined with iodine 131 on the basis of methimazole,which can effectively reduce the thyroid function index,improve bone metabolism function,and does not increase adverse reactions,the safety is ideal.
作者
丁颖
张杨
孙潇潇
DING Ying;ZHANG Yang;SUN Xiaoxiao(Department of Endocrinology,Shuyang County Hospital of Traditional Chinese Medicine,Suqian,Jiangsu Province,223600 China)
出处
《中外医疗》
2023年第28期94-97,共4页
China & Foreign Medical Treatment
