摘要
恶心、呕吐是化疗比较常见的不良反应,同时也可导致患者生活质量下降、营养缺乏、炎症反应、免疫力下降等不良后果。目前西医止吐药有5-羟色胺3受体拮抗剂、神经激肽1受体拮抗剂、糖皮质激素等,虽然有一定效果,但会产生其他的不良反应。通过查阅相关文献,发现肠道菌群与化疗引起的消化道反应及治疗密切相关,本文就化疗产生恶心、呕吐的西医机制、中医理论与肠道菌群的相关性,以及通过健脾类中药方剂、益生菌调节肠道菌群,治疗化疗引起的恶心、呕吐做以综述,并针对目前该研究领域存在的问题提出建议,以期为临床应用及临床试验提供参考。
Nausea and vomiting are common side effects of chemotherapy,which can also lead to poor quality of life,nutritional deficiency,inflammation,immunity,and other adverse consequences.At present,western antiemesis drugs have 5-hydroxytryptamine 3 receptor antagonists,neurokinin 1 receptor antagonists,glucocorticoids,and so on.Although they have certain effects,they will produce other adverse reactions.By reviewing relevant literatures,it is found that intestinal flora is closely related to the digestive tract reaction caused by chemotherapy and treatment.This paper reviews the western medicine mechanism of nausea and vomiting caused by chemotherapy,the correlation between traditional Chinese medicine theory and intestinal flora,and the regulation of intestinal flora through spleen-strengthening Chinese medicine prescriptions,and probiotics to treat nausea and vomiting caused by chemotherapy.Some suggestions are put forward for the problems in this research field so as to provide reference for clinical application and clinical trials.
作者
杨秋燕
肖海娟
马玉媛
李亚楠
赵景涛
秦悦
YANG Qiuyan;XIAO Haijuan;MA Yuyuan;LI Yanan;ZHAO Jingtao;QIN Yue(Shaanxi University of Chinese Medicine,Shaanxi Province,Xianyang 712046,China;Department of Oncology,Affiliated Hospital of Shaanxi University of Chinese Medicine,Shaanxi Province,Xianyang 712000,China)
出处
《中国医药导报》
CAS
2023年第32期43-46,共4页
China Medical Herald
基金
国家自然科学基金资助项目(82074255)
陕西省自然科学基础研究计划项目(2020JM-591)
陕西中医药大学学科创新团队建设项目(2019-YL06)。
关键词
化疗
恶心
呕吐
肠道菌群
中药复方
益生菌
相关性
Chemotherapy
Nausea
Vomiting
Intestinal flora
Traditional Chinese medicine compound
Probiotics
Relevance
