摘要
目的观察补肺健脾法对有基础疾病的新型冠状病毒感染老年患者的临床疗效及其对实验室检测指标的影响。方法符合纳入标准的确诊患者142例(治疗组),体检中心60岁以上有基础疾病的老年人108例(新型冠状病毒感染阴性)(对照组),治疗组患者常规西药对症治疗的基础上加用补肺健脾法,连续治疗10 d后,比较患者治疗前后及对照组的实验室血常规、炎症因子指标、肝肾功能指标、冠心病有关检测指标等,并观察患者治疗前实验室指标与性别的相关性。结果新型冠状病毒感染患者炎症指标显著升高,肝肾功能和心肌损害及凝血指标出现不同程度异常,男性患者的C反应蛋白(CRP)、血肌酐(Scr)、凝血酶原时间(PT)、国际标准比率(INR)明显高于女性患者。补肺健脾法治疗后,患者的血白细胞(WBC)、中性粒细胞(NEU)、淋巴细胞计数(LYM)、CRP、谷氨酸-丙酮酸转氨酶(ALT)、AST、Scr较治疗前明显下降;患者的肌酸激酶同工酶(CK-MB)、肌红蛋白(MB)等指标较治疗前显著改善(P<0.05);患者的纤维蛋白原(FIB)、部分活化凝血酶原时间(APTT)、D-二聚体、纤维蛋白降解产物(FDP)等指标较治疗前显著下降(P<0.05)。经补肺健脾法治疗后,男性和女性的实验室检测指标无显著差异。结论老年男性和女性新型冠状病毒感染后实验室检测指标存在显著差异。补肺健脾法对于伴有基础疾病的老年新型冠状病毒感染患者疗效显著,可减轻患者的炎症反应,改善其免疫功能,改善肝肾功能和心功能,利于恢复,治疗后男女实验室指标无差异。
Objective To observe the clinical efficacy of spleen-strengthening and lung-supplementing method in the treatment of corona virus disease 2019(COVID-19)patients with basic diseases and its influence on laboratory indicators.Methods 142 patients with confirmed COVID-19 who met the inclusion criteria were classified as treatment group and 108 elderly people over 60 years old with basic diseases(negative for COVID-19)from the physical examination center were classified as control group.Patients of treatment group were treated with spleen-strengthening and lung-supplementing method based on routine Western medicine symptomatic treatment.After continuous treatment for 10 days,the clinical efficacy of patients before and after treatment was compared,as well as the laboratory blood routine,inflammatory factor indicators,liver and kidney function indicators,coronary heart disease related detection indicators.The correlation between laboratory indexes and gender before treatment was also observed.Results The inflammatory indexes of patients with COVID-19 were significantly increased,liver and kidney functions,myocardial damage and coagulation indexes were abnormal to varying degrees.The C-reactive protein(CRP),serum creatinine(Scr),prothrombin time(PT),and international normalized ratio(INR)of male patients were significantly higher than those of female patients.After the treatment of spleen-strengthening and lung-supplementing method,white blood cells count(WBC),neutrophil(NEU),lymphocyte(LYM),and CRP of patients were decreased;Alanine aminotransferase(ALT),aspartate aminotransferase(AST),Scr and other indicators of liver and kidney function were also significantly decreased;The indexes of creatine kinase MB(CK-MB),myoglobin(MB),fibrinogen(FIB),PT,activated partial thromboplastin time(APTT),D-dimer,and fibrinogen degradation products(FDP)were also significantly decreased(P<0.05).After treatment with spleen-strengthening and lung-supplementing method,there was no significant difference in laboratory test indicators between males and females.Conclusion The symptoms of men with COVID-19 are more serious than those of women.The method of spleen-strengthening and lungsupplementing method has a significant effect on the elderly COVID-19 patients with basic diseases.It can reduce the inflammatory reaction,improve their immune function,improve liver and kidney function and cardiac function,and is conducive to recovery.There was no significant difference in laboratory test indexes between males and females after treatment.
作者
李深广
金龙妹
张莺
吴定中
吴宏进
朱珀
罗婕萌
吴伟斌
张腾
LI Shenguang;JIN Longmei;ZHANG Yin;WU Dingzhong;WU Hongjin;ZHU Po;LUO Jiemeng;WU Weibin;ZHANG Teng(Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai Minhang Integrated Traditional Chinese and Western Medicine Hospital,Shanghai 201199,China;Shanghai Maternity and Child Care Hospital,Shanghai 201102,China;Longhua Hospital of Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai 200437,China)
出处
《辽宁中医药大学学报》
CAS
2023年第11期215-220,共6页
Journal of Liaoning University of Traditional Chinese Medicine
基金
上海市闵行区中医特色品牌专科建设项目(ZYPP-03)
上海市闵行区名老中医工作室建设项目(mhmlzy01)
上海市治未病技术处方项目(ZY2021-2023-0104-02-JS-30)。
