摘要
目的探究卡培他滨同步放化疗对局部进展期直肠癌预后及免疫功能的影响。方法抽取2019年2月至2022年2月周口市中心医院收治的204例局部进展期晚期直肠癌患者为研究对象,采用抽签法将其随机分为观察组与对照组,每组102例。对照组术后行放疗治疗,观察组术后行卡培他滨同步放化疗治疗。收集两组患者的一般资料,比较两组患者近期、远期临床疗效及不良反应发生情况,采用免疫比浊法检测两组患者治疗前后免疫球蛋白A(IgA)、免疫球蛋白G(IgG)和免疫球蛋白M(IgM)水平,以流式细胞仪检测两组患者的血清T辅助/诱导细胞亚群(CD3^(+)CD4^(+))、自然杀伤细胞群(CD3^(+)CD56^(+))、T抑制/细胞毒性细胞亚群(CD3^(+)CD4^(+)/CD3^(+)CD8^(+))水平。结果观察组TNM分期降期率(81.37%,83/102)、手术根治性切除率(90.20%,82/102)、1年生存率(99.02%,101/102)均高于对照组(63.73%,65/102;72.55%,74/102;93.14%,95/102),P均<0.05;观察组局部复发率(11.76%,12/102)、远期转移率(14.71%,15/102)低于对照组(24.51%,25/102;30.39%,31/102),P<0.05。两组患者乏力发生情况比较差异有统计学意义(P<0.05),其他不良反应发生情况比较差异均未见统计学意义(P均>0.05)。治疗后,两组患者免疫球蛋白和T细胞水平均高于治疗前(P均<0.05),且观察组高于对照组(P<0.05)。结论卡培他滨同步放化疗对局部进展期直肠癌预后效果较好,还能改善机体的免疫功能。
Objective To investigate the effect of capecitabine-based chemoradiotherapy on prognosis and immune function in patients with locally advanced rectal cancer.Methods Two hundred and four patients with locally advanced rectal cancer admitted to Zhoukou Central Hospital from February 2019 to February 2022 were selected as research objects,and they were randomly divided into observation group and control group by drawing straws,with 102 cases in each group.The control group received postoperative radiotherapy,while the observation group was given capecitabine-based chemoradiotherapy after surgery.The general data of the two groups were collected.The short-term and long-term clinical efficacy,incidence of adverse reactions of the two groups were compared.The levels of immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)of the two groups were detected by immunonephelometry.The levels of T helper/inducer cell subsets(CD3^(+)CD4^(+)),natural killer cell sets(CD3^(+)CD56^(+)),and T suppressor/cytotoxic cell subsets(CD3^(+)CD4^(+)/CD3^(+)CD8^(+))of the two groups were measured by flow cytometer.Results The tumor node and metastasis(TNM)stage reduction rate(81.37%,83/102),radical resection rate(90.20%,82/102)and 1-year survival rate(99.02%,101/102)in the observation group were higher than those in the control group(63.73%,65/102;72.55%,74/102;93.14%,95/102),all P<0.05.The local recurrence rate(11.76%,12/102)and long-term metastasis rate(14.71%,15/102)in the observation group were lower than those in the control group(24.51%,25/102;30.39%,31/102),P<0.05.There was a significant difference in the occurrence of fatigue between the two groups(P<0.05),but no significant difference in incidence of other adverse reactions(all P>0.05).After treatment,the levels of immunoglobulin and T cells in both groups were higher than those before treatment(all P<0.05),and the levels of serum immunoglobulin and T cells in the observation group were higher than those in the control group(P<0.05).Conclusions Performing capecitabine-based chemoradiotherapy for locally advanced rectal cancer can achieve good prognosis and effectively improve the immune function in patients.
作者
于飞洪
Yu Feihong(WardⅡ,Department of Radiotherapy,Zhoukou Central Hospital,Zhoukou 466000,China)
出处
《中国实用医刊》
2023年第19期20-23,共4页
Chinese Journal of Practical Medicine
关键词
卡培他滨
进展期直肠癌
预后
免疫功能
Capecitabine
Locally advanced rectal cancer
Prognosis
Immune function
