摘要
Ferroptosis,a distinctive form of programmed cell death,is involved in numerous diseases with specific characteristics,including certain cell morphology,functions,biochemistry,and genetics,that differ from other forms of programmed cell death,such as apoptosis.Many studies have explored ferroptosis and its associated mechanisms,drugs,and clinical applications in diseases such as kidney injury,stroke,ischemia-reperfusion injury,and prostate cancer.In this review,we summarize the regulatory mechanisms of some ferroptosis inducers,such as enzalutamide and erastin.These are current research focuses and have already been studied extensively.In summary,this review focuses on the use of ferroptosis induction as a therapeutic strategy for treating tumors of the urinary system.
基金
supported by the National Natural Science Foundation of China(No.81974395,No.82173036)
Guangdong Basic and Applied Basic Research Foundation(No.2019A1515011437)
International Science and Technology Cooperation Project Plan of Guangdong Province(No.2021A0505030085)
Sun Yat-Sen University Clinical Research 5010 Program(No.2019005)
Sun Yat-Sen Clinical Research Cultivating Program(No.201702)
Guangdong Province Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation(No.2020B1212060018OF006)
Guangdong Provincial Clinical Research Center for Urological Diseases(No.2020B1111170006)
Beijing Bethune Charitable Foundation(No.mnzl202001)and the Chinese National Scholarship.
