摘要
目的探讨复方多黏菌素B软膏联合窄谱红光照射对肛周脓肿患者术后创面愈合及血清表皮生长因子(EGF)、白细胞介素-33(IL-33)水平的影响。方法选择2022年2-6月于北京中医药大学孙思邈医院/铜川市中医医院治疗的96例肛周脓肿患者为研究对象,采用随机数字表法分为对照组、研究组,每组48例。两组均进行切开引流术治疗肛周脓肿,对照组术后采用常规抗菌药物抗感染治疗,研究组在对照组基础上采用复方多黏菌素B软膏联合窄谱红光照射治疗,比较两组治疗后临床疗效、创面愈合情况及健康状况调查简表(SF-36)评分,以及治疗前后血清EGF、IL-33水平。结果治疗后,研究组治疗总有效率(93.75%)明显高于对照组(77.08%),差异有统计学意义(P<0.05)。治疗后,研究组创面肉芽组织生长情况评分、创面分泌物评分、视觉模拟量表(VAS)评分均明显低于对照组,创面愈合时间明显短于对照组,差异有统计学意义(P<0.05)。治疗后,两组躯体健康、心理健康、社会功能、日常生活状况评分均明显高于治疗前,且治疗后研究组以上评分均明显高于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清EGF水平明显升高,IL-33水平明显降低,与治疗前比较,差异有统计学意义(P<0.05)。治疗后,研究组EGF水平明显高于对照组,IL-33水平明显低于对照组,差异有统计学意义(P<0.05)。结论复方多黏菌素B软膏联合窄谱红光照射治疗肛周脓肿患者有利于创面愈合,能够缓解肛周脓肿术后疼痛,提高血清EGF水平,降低IL-33水平,提高患者生活质量,临床疗效明显。
Objective To investigate the effects of compound polymyxin B ointment combined with narrow spectrum red light irradiation on wound healing and serum epidermal growth factor(EGF)and interleukin-33(IL-33)levels in patients with perianal abscess after surgery.Methods A total of 96 patients with perianal abscess treated in Sun Simiao Hospital Affiliated to Beijing University of Chinese Medicine/Tongchuan Hospital of Traditional Chinese Medicine from February to June 2022 were selected as the study objects and divided into control group and study group according to the random number table method,with 48 cases in each group.Perianal abscess was treated by incision and drainage in both groups.The control group received conventional anti-infection treatment after surgery,and the study group received compound polymyxin B ointment combined with narrow spectrum red light irradiation on the basis of the control group.The clinical efficacy,wound healing and Health Status Survey Summary Form(SF-36)score after treatment,and serum EGF and IL-33 levels before and after treatment were compared between the two groups.Results After treatment,the total effective rate of the study group(93.75%)was significantly higher than that of the control group(77.08%),the difference was statistically significant(P<0.05).After treatment,the score of wound granu-lation tissue growth,wound secretion score and visual analog scale(VAS)score of the study group were sig-nificantly lower than those of the control group,and the wound healing time was significantly shorter than that of the control group,with statistical significance(P<0.05).After treatment,the scores of physical health,mental health,social function and daily living status in the two groups were significantly higher than those before treatment,after treatment the above scores of the study group were significantly higher than those of the control group,with statistical significance(P<0.05).After treatment,the EGF level increased significantly and IL-33 level decreased significantly in both groups,the differences compared with those before treatment were statistically significant(P<0.05).After treatment,the EGF level in the study group was sig-nificantly higher than that in the control group,and the IL-33 level was significantly lower than that in the control group,with statistical significance(P<0.05).Conclusion The treatment of patients with perianal ab-scess with compound polymyxin B ointment combined with narrow spectrum red light irradiation is beneficial to wound healing,which can relieve postoperative pain,increase serum EGF level,reduce IL-33 level,improve the quality of life of patients,and has obvious clinical effects.
作者
陈静
惠瞳
CHEN Jing;HUI Tong(Department of Anorectal Medicine,Sun Simiao Hospital Affiliated to Beijing University of Chinese Medicine/Tongchuan Hospital of Traditional Chinese Medicine,Tongchuan,Shaanxi 727100,China;Department of Anorectal Surgery,Shaanxi Provincial People's Hospital,Xi'an,Shaanxi 710061,China)
出处
《检验医学与临床》
CAS
2023年第22期3328-3331,3335,共5页
Laboratory Medicine and Clinic
