摘要
目的:探讨结直肠息肉与脂代谢异常相关性,研究结直肠息肉发病可能的机制,为结直肠癌的筛查提供可行的参考指标。方法:收集2021年1月至2022年6月就诊于蚌埠医学院第一附属医院行电子肠镜检查的151例患者的临床资料,根据电子肠镜检查结果分为息肉组(实验组)及非息肉组(对照组),回顾性分析研究对象的总胆固醇(Total cholesterol,TC)、年龄、甘油三酯(Triglyceride,TG)、性别、高密度脂蛋白(High density lipoprotein cholesterol,HDL-C)、营养状况、低密度脂蛋白(Low density lipoprotein cholesterol,LDL-C)等参考指标;采用Logistic多因素回归模型分析结直肠息肉发病的危险因素。结果:实验组与对照组年龄、血清凝血酶原时间、凝血酶原活动度、白蛋白、丙氨酸氨基转移酶、天门冬氨酸转移酶、血红蛋白、白细胞、红细胞、血小板等差异无统计学意义(P>0.05);实验组TC、LDL-C、TG水平高于对照组,HDL-C水平低于对照组,差异有统计学意义(P<0.05);多因素Logistic回归分析发现TC、LDL-C、HDL-C是结直肠息肉发病的独立危险因素。结论:血脂代谢异常与结直肠息肉的发病密切相关,控制人群中的血脂代谢水平可有效减少结直肠息肉的发病。
Objective:To explore the correlation between colorectal polyps and abnormal lipid metabolism,and to study the possible mechanism of colorectal polyps,so as to provide a feasible reference index for the screening of colorectal cancer.Methods:A retrospective analysis was performed on the clinical data of 151 patients who underwent electronic colonoscopy in the First Affiliated Hospital of Bengbu Medical College from January 2021 to June 2022.According to the results of electronic colonoscopy,the patients were divided into polyps group(experimental group)and non-polyps group(control group).The differences of total cholesterol(TC),age,triglyceride(TG),sex,high density lipoprotein cholesterol(HDL-C),nutritional status,low density lipoprotein cholesterol(LDL-C)and other reference indexes were compared between the two groups.Multivariate Logistic regression was used to analyze the risk factors of colorectal polyps and abnormal lipid metabolism.Results:There were no significant differences in age,serum prothrombin time,prothrombin activity,albumin,alanine aminotransferase,aspartate transferase,hemoglobin,white blood cells,red blood cells,platelets between the polyps group and the non-polyps group(P>0.05);The levels of TC、LDL-C、TG in the polyps group were significantly higher than those in the non-polyps group(P<0.05);The level of high density lipoprotein cholesterol(HDL-C)was significantly lower than that of non-polyps group(P<0.05);TC、LDL-C、HDL-C were independent risk factors of colorectal polyps.Conclusion:Abnormal blood lipid metabolism is closely associated with the incidence of the colorectal polyps.Controlling the level of blood lipid metabolism of the population can effectively reduce the incidence of colorectal polyps.
作者
王猛
欧伟丽
王启之
韦君
邓晓晶
马振增
任志
WANG Meng;OU Wei-li;WANG Qi-zhi;WEI Jun;DENG Xiao-jing;MA Zhen-zeng;REN Zhi(Department of Gastroenterology,The First Affiliated Hospital of Bengbu Medical College;Department of General Practice,The Second Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui 233000)
出处
《赣南医学院学报》
2023年第9期971-974,共4页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
基金
蚌埠医学院自然科学重点项目(2020byzd116)。
关键词
结直肠息肉
血脂代谢
危险因素
Colorectal polyps
Lipid metabolism
Risk factors
