摘要
Aggregation-Induced Emission luminogen(AIEgen)possess great potential in enhancing bioimaging-guided radiotherapeutic effects and radioimmunotherapy to improve the therapeutic effects of the tumor with good biosafety.Bacteria as a natural carrier have demonstrated great advantages in tumor targeted delivery and penetration to tumor.Herein,we construct a delivery platform that Salmonella VNP20009 act as an activated bacteria vector loaded the as-prepared novel AIEgen(TBTP-Au,VNP@TBTP-Au),which showed excellent radioimmunotherapy.VNP@TBTP-Au could target and retain AIEgen at the tumor site and deliver it into tumor cells specially,upon X-ray irradiation,much ROS was generated to induce immunogenic cell death via cGAS-STING signaling pathway to evoke immune response,thus achieving efficient radioimmunotherapy of the primary tumor with good biosafety.More importantly,the radioimmunotherapy with VNP@TBTP-Au formatted good abscopal effect that was able to suppress the growth of distant tumor.Our strategy pioneer a novel and simple strategy for the organic combination of bacteria and imaging-guided radiotherapy,and also pave the foundation for the combination with immunotherapy for better therapeutic effects.
基金
the National Natural Science Foundation of China(82102904)
the Science,Technology&Innovation Commission of Shenzhen Municipality(Nos.JCYJ20190807144605514,JCYJ20210324113405014,JCYJ20210324113810029 and JCYJ20190808154213097)
Guangdong Basic and Applied Basic Research Foundation(No.2022A1515110534)
Medical Science and Technology Foundation of Guangdong Province(No.A2022122)
Scientific research project of Guangdong Bureau of traditional Chinese Medicine(20231002)
Science and Technology Program of Guangzhou(No.2023A04J0535)
Start-up Funding for the National Natural Project of Guangdong Provincial People’s Hospital in 2022(No.8220070617).
