摘要
目的研究鱼肝油软膏联合地奈德乳膏治疗儿童变应性接触性皮炎(ACD)的疗效及对患儿皮损皮肤屏障的修复效果。方法选取ACD患儿80例随机分为对照组和试验组,每组各40例。对照组给予地奈德乳膏治疗,试验组给予鱼肝油软膏联合地奈德乳膏治疗。治疗2周后,比较两组患儿治疗前后主客观症状评分及皮肤屏障功能指标[角质层含水量、表皮油脂含量及表皮水分丢失量(TEWL)]的变化,以及两组疗效。Spearman相关性分析试验组临床疗效与角质层含水量、表皮油脂含量及TEWL的相关性。结果治疗后,两组局部烧灼感、瘙痒、丘疹、红斑等症状体征评分及水疱数目均较前降低(P<0.01);且试验组上述评分均低于对照组(P<0.05)。两组表皮油脂含量、角质层含水量均较前升高(P<0.05),TEWL则较前降低(P<0.05);且试验组各项皮肤屏障功能指标均优于对照组(P<0.05)。试验组临床疗效高于对照组(92.50%vs.75.00%,P<0.05)。试验组总有效率与表皮油脂含量、角质层含水量呈正相关(r_(s)=0.496,0.438,P<0.05),与TEWL水平呈负相关(r_(s)=-0.483,P<0.05)。结论鱼肝油软膏联合地奈德乳膏治疗儿童ACD,可以有效缓解局部病灶症状,修复损伤皮肤屏障,优于单用地奈德乳膏治疗。
Objective To explore the effect of cod liver oil ointment combined with desonide cream in the treatment of allergic contact dermatitis(ACD)in children and the repair effect of skin barrier.Methods 80 children with ACD were selected,and were randomly divided into control group and experimental group,with 40 children in each group.The control group were treated with desonide cream,and the experimental group were treated with cod liver oil ointment combined with desonide cream.After 2 weeks of the treatment,the changes in subjective and objective symptom scores and index of skin barrier[cuticle water content,epidermal oil content and through epidermal water loss(TEWL)]before and after treatment were compared in control group and experimental group.The total effective rates were compared between the two groups.Spearman method was used to analyze the correlation among the clinical efficacy of the experimental group and the cuticle water content,epidermal oil content,and TEWL.Results After treatment,the scores of local pruritus,burning sensation,erythema,papule,blister,skin lesion area and other symptoms in control group and experimental group were decreased in varying degrees(P<0.01),and the above scores in experimental group were lower than those in control group(P<0.05).After treatment,the epidermal oil content and cuticle water content in control group and experimental group were increased in varying degrees(P<0.05),and TEWL were decreased(P<0.01).The epidermal oil content and cuticle water content in experimental group were higher than those in control group,and TEWL was lower than that in control group(P<0.05).After treatment,the clinical efficacy of experimental group was higher than that of control group(92.50%vs.75.00%,P<0.05).The total effective rate of the experimental group after treatment was positively correlated with the content of epidermal oil and water in the stratum corneum(r_(s)=0.496,0.438,P<0.05),and negatively correlated with the level of TEWL(r_(s)=-0.483,P<0.05).Conclusion Cod liver oil ointment combined with desonide cream than Desonide cream can effectively relieve the symptoms of local focus in the clinical treatment of children's ACD,and repair the damaged skin barrier,which is superior to the treatment with desonide cream alone.
作者
曾颖
高春芳
付桂莉
柯欢
杨倩
Ying ZENG;Chun-Fang GAO;Gui-Li FU;Huan KE;Qian YANG(Department of Dermatology,Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital),Huazhong University of Science&Technology,Wuhan 430019,China)
出处
《药物流行病学杂志》
CAS
2023年第8期856-861,共6页
Chinese Journal of Pharmacoepidemiology
基金
武汉市卫生健康科研基金资助项目(WX19Y01)。
