摘要
硒元素作为人体中一种重要的微量元素,主要以硒蛋白的形式发挥作用,与自身免疫性疾病(autoimmune diseases,AIDs)的保护作用密切相关,在自身免疫性损伤、抗氧化应激、保护细胞凋亡各方面作用显著。目前AIDs发病机制尚不明确,现有治疗手段也无法完全治愈,近期相关研究发现硒蛋白在AIDs中起重要保护作用。文章从硒元素在AIDs中的生物学功能、干预机制及治疗效果等方面进行总结,综述硒蛋白在自身免疫性甲状腺疾病(autoimmune thyroid disease,AITD)、类风湿关节炎(rheumatoid arthritis,RA)、强直性脊柱炎(ankylosing spondylitis,AS)、炎症性肠病(inflammatory bowel disease,IBD)、系统性红斑狼疮(systemic lupus erythematosus,SLE)、干燥综合征(Sj?gren’’s syndrome,SS)、系统性血管炎(systemic vasculitis,SV)、1型糖尿病(type 1 diabetes,T1DM)等AIDs中的保护作用及生物学功能,为AIDs的防治提供依据。
As an important trace element in the human body,selenium mainly plays a role in the form of selenoprotein,which is closely related to the protective effect of autoimmune diseases(AIDs),and plays a significant role in various aspects of autoimmune injury,anti-oxidative stress and protection against apoptosis.At present,the pathogenesis of AIDs is not clear,and the existing treatment means cannot cure it completely.Recently,some studies have found that selenoproteins play an important protective role in AIDs.In this paper,the biological functions,intervention mechanisms and therapeutic effects of selenium in AIDs are summarized,and the protective effect and biological function of selenium protein in AIDs such as autoimmune thyroid disease(AITD),rheumatoid arthritis(RA),ankylosing spondylitis(AS),inflammatory bowel disease(IBD),systemic lupus erythematosus(SLE),Sjögren's syndrome(SS),systemic vasculitis(SV),and type 1 diabetes(T1DM),so as to provide a basis for the prevention and treatment of AIDs.
作者
余华棋
冉瑞金
Yu Huaqi;Ran Ruijin(Health Science Center,Hubei Minzu University,Enshi 445000,China;Department of Ophthalmology,Affiliated Hospital of Hubei University for Nationalities,Enshi 445000,China;Hubei Key Laboratory of Pathogenesis and Intervention of Rheumatic Diseases,Enshi 445000,China)
出处
《国际免疫学杂志》
CAS
2023年第5期574-579,共6页
International Journal of Immunology
基金
湖北省卫生健康委员会2019~2020年度青年人才项目(WJ2019Q024)。
关键词
硒
硒蛋白
自身免疫性疾病
微量元素
Selenium
Selenoprotein
Autoimmune diseases
Trace element
