摘要
目的:探讨内镜下胃癌活检组织中组织蛋白酶D(CTSD)和人类表皮生长因子受体2(HER2)表达及意义。方法:选取行内镜活检的胃癌患者81例为研究对象。通过免疫组化法检测胃癌活检组织中CTSD、HER2的表达,并进行随访。分析两者表达与胃癌患者临床病理特征的关系。绘制Kaplan-Meier曲线分析两者表达与胃癌患者预后的关系;采用Cox比例风险回归模型分析胃癌患者预后的影响因素。结果:CTSD和HER2在胃癌活检组织中阳性表达率分别为46.91%、20.99%。CTSD表达与胃癌分化程度、淋巴结转移及临床分期有关(均P<0.05)。HER2表达与胃癌分化程度、Lauren分型、淋巴结转移及临床分期有关(均P<0.05)。CTSD表达阳性患者5年生存率低于CTSD表达阴性患者5年生存率(26.32%与55.81%,P<0.05)。HER2表达阳性患者5年生存率与阴性患者比较,差异无统计学意义(29.41%与45.31%,P>0.05)。Lauren分型、HP感染、淋巴结转移、临床分期及CTSD表达为胃癌患者预后的独立影响因素(均P<0.05)。结论:胃癌活检组织中CTSD和HER2的表达与胃癌分化程度、淋巴结转移等临床病理特征相关,且CTSD表达可作为胃癌患者预后的独立影响因素。
Objective:To investigate the expression and significance of cathepsin D(CTSD)and human epidermal growth factor receptor 2(HER2)in endoscopic gastric cancer biopsy.Methods:A total of 81 patients with gastric cancer who underwent endoscopic biopsy were selected as subjects.The expressions of CTSD and HER2 in gastric cancer biopsy tissues were detected by immunohistochemistry and followed up.The relationship between their expression and clinicopathologic features in patients with gastric cancer was analyzed.Kaplan-Meier curve was drawn to analyze the relationship between their expression and prognosis in patients with gastric cancer.Cox proportional risk regression model was used to analyze the prognostic factors of patients with gastric cancer.Results:The positive expression rates of CTSD and HER2 in gastric cancer biopsy were 46.91%and 20.99%,respectively.The expression of CTSD was correlated with the differentiation degree,lymph node metastasis and clinical stage of gastric cancer(all P<0.05).The expression of HER2 was correlated with the differentiation degree of gastric cancer,Lauren’s classification,lymph node metastasis and clinical stage(all P<0.05).The 5-year survival rate of patients with positive CTSD expression was lower than that of patients with negative CTSD expression(26.32%vs.55.81%,P<0.05).There was no significant difference in 5-year survival rate between HER2-positive patients and negative patients(29.41%vs.45.31%,P>0.05).Lauren’s classification,HP infection,lymph node metastasis,clinical stage and CTSD expression were independent factors influencing the prognosis of gastric cancer patients(all P<0.05).Conclusion:The expression of CTSD and HER2 in gastric cancer biopsy tissues is correlated with the degree of differentiation of gastric cancer,lymph node metastasis and other clinicopathologic features,and CTSD expression can be an independent prognostic factor for patients with gastric cancer.
作者
韩少静
郭永泽
郑扬
陈旭峰
宗静
向正国
HAN Shaojing;GUO Yongze;ZHENG Yang;CHEN Xufeng;ZONG Jing;XIANG Zhengguo(Department of Gastroenterology,the 904 Hospital of the Joint Service Support Force of PLA,Wuxi 214101,China)
出处
《陕西医学杂志》
CAS
2023年第9期1249-1253,共5页
Shaanxi Medical Journal
基金
河北省科学技术厅资助项目(202130821010208)。
关键词
胃癌
组织蛋白酶D
人类表皮生长因子受体2
临床病理特征
预后
Gastric cancer
Cathepsin D
Human epidermal growth factor receptor 2
Clinicopathological characteristics
Prognosis
