摘要
目的探讨血清甲胎蛋白、血小板指标联合检测用于临床诊断乙型肝炎肝硬化肝癌患者的价值。方法选择2022年1—12月在滕州市中医医院接受治疗的乙型肝炎肝硬化肝癌患者60例作为观察组,选择同期在本院接受体检的健康者60例作为对照组,均进行血小板指标及血清甲胎蛋白指标检测,分析两组各项指标结果统计学差异,分别计算甲胎蛋白指标及血小板指标单一检测与联合检测的敏感度及特异性。结果观察组患者甲胎蛋白检测结果(345.95±11.23)ng/mL明显高于对照组,血小板平均容积(9.23±0.54)fL、血小板计数(114.94±10.03)×10^(9)/L、血小板分布宽度(14.01±0.47)fL、血小板压积(0.12±0.02)%低于对照组,差异有统计学意义(t=228.650、17.425、36.203、22.619、19.335,P<0.05)。甲胎蛋白联合血小板四项指标检测特异度明显高于单一指标检测,差异有统计学意义(P<0.05)。结论临床鉴别诊断乙型肝炎肝硬化肝癌疾病可通过检测血清甲胎蛋白及血小板指标的方式,具有极高的敏感度与特异性。
Objective To explore the value of combined detection of serum alpha-fetoprotein and platelet index for clinical diagnosis of hepatitis B cirrhosis and hepatocellular carcinoma patients.Methods 60 patients with hepatitis B cirrhosis and hepatocellular carcinoma treated in Tengzhou Hospital of Traditional Chinese Medicine from January to December 2022 were selected as the observation group.Sixty cases of healthy people who received physical exami⁃nation in our Hospital during the same period were selected as the control group.They all tested platelet index and serum alpha-fetoprotein index.Statistical differences between two groups were analyzed.The sensitivity and specific⁃ity of the single test and the combined test of alpha-fetoprotein index and platelet index were calculated respectively.Results The results of alpha-fetoprotein(345.95±11.23)ng/mL of patients in the observation group were significantly higher than that of the control group,the mean platelet volume(9.23±0.54)fL,platelet count(114.94±10.03)×10^(9)/L,platelet distribution width(14.01±0.47)fL,and platelet pressure accumulation(0.12±0.02)%of the patients in the ob⁃servation group were lower than those in the control group,and the difference was statistically significant(t=228.650,17.425,36.203,22.619,19.335,P<0.05).The specificity of the four indexes of alpha-fetoprotein combined with plate⁃lets was significantly higher than that of the single indexes,and the difference was statistically significant(P<0.05).Conclusion Clinical differential diagnosis of hepatitis B cirrhosis and hepatocellular carcinoma can be done by detect⁃ing serum alpha-fetoprotein and platelet indexes,which has high sensitivity and specificity.
作者
张文凤
杨霞
王培柱
ZHANG Wenfeng;YANG Xia;WANG Peizhu(Department of Laboratory,Tengzhou Hospital of Traditional Chinese Medicine,Tengzhou,Shandong Province,277500 China;Department of Laboratory,Feicheng Hospital of Traditional Chinese Medicine,Hefei,Anhui Prov-ince,271600 China)
出处
《系统医学》
2023年第12期6-9,共4页
Systems Medicine
关键词
血清甲胎蛋白
血小板
检测诊断
乙型肝炎肝硬化肝癌
价值
Serum alpha-fetoprotein
Platelet
Diagnosis
Hepatitis B cirrhosis hepatocellular carcinoma
Value
