摘要
目的探讨天麻素注射液联合静脉溶栓治疗急性脑梗死疗效及对患者氧化应激指标、血清炎症因子水平的影响。方法选取自2020年1月至2023年1月收治的102例急性脑梗死患者为研究对象,根据不同的治疗方法分为常规组和联合组,每组各51例。比较两组的治疗效果、血清炎症因子水平变化、改良Rankin评分量表(MRS)评分变化、美国国立卫生研究院卒中量表(NIHSS)评分变化、谷胱甘肽过氧化酶(GSH-Px)、丙二醛(MDA)、超氧化物歧化酶(SOD)、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)及不良反应发生情况。结果联合组的治疗有效率为90.2%(46/51),显著高于常规组的74.5%(38/51),差异有统计学意义(P<0.05)。治疗前,两组患者TNF-α、CRP、MRS评分、NIHSS评分、GSH-Px、MDA、SOD比较,差异无统计学意义(P>0.05)。治疗后,两组患者TNF-α、CRP、MRS评分、NIHSS评分、GSH-Px、MDA、SOD指标均改善,联合组改善更显著,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论天麻素注射液联合静脉溶栓治疗急性脑梗死疗效显著,安全可靠。
Objective To observe the therapeutic effect of gastrodin injection combined with intravenous thrombolysis on acute cerebral infarction and the effects of oxidative stress index and serum inflammatory factors.Methods A total of 102 patients with acute cerebral infarction treated from January 2020 to January 2023 were selected as the study objects and divided into conventional group and combination group according to different treatment methods,with 51 cases in each group.The therapeutic effects,serum inflammatory factor levels,modified Rankin score Scale(MRS)score,National Institutes of Health Stroke Scale(NIHSS)score,glutathione peroxidase(GSH-Px),malondialdehyde(MDA),superoxide dismutase(SOD),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),the occurrence of adverse reactions were compared between the two groups.Results The effective rate of the combination group was 90.2%(46/51),which was significantly higher than that of the conventional group[74.5%(38/51)],and the difference was statistically significant(P<0.05).Before the treatment,TNF-α,CRP,MRS Score,NIHSS score,GSH-Px,MDA and SOD were compared between two groups,and There was no significant difference(P>0.05).After treatment,TNF-α,CRP,MRS Score,NIHSS score,GSH-Px,MDA and SOD indexes were all improved in the two groups,and the improvement was more significant in observation group,with statistical significance(P<0.05).There was no significant difference in the rate of adverse reactions between the two groups(P>0.05).Conclusion Gastrodin injection combined with intravenous thrombolysis in the treatment of acute cerebral infarction is effective,safe and reliable.
作者
周娟
陈娇
王娟
ZHOU Juan;CHEN Jiao;WANG Juan(Department of Neurology,Meishan Second People’s Hospital,Meishan 620500,China)
出处
《创伤与急危重病医学》
2023年第4期278-281,共4页
Trauma and Critical Care Medicine
关键词
急性脑梗死
天麻素注射液
静脉溶栓
治疗效果
不良反应
血清炎症因子水平
Acute cerebral infarction
Gastrodin injection
Intravenous thrombolysis
Therapeutic effect
Adverse reaction
Serum levels of inflammatory cytokines
