摘要
帕金森病(Parkinson’s disease, PD)为常见的神经退行性疾病,临床表现以运动障碍为主,常导致日常活动受限、生活质量下降,并最终残疾。结构MRI中的三维T1加权成像(three dimensions T1-weighted imaging, 3D-T1WI)和扩散张量成像(diffusion-tensor imaging, DTI)可对PD患者灰质和白质的微观结构变化进行定量分析。近年来,基于3D-T1WI的相关研究显示震颤型(tremor-dominant, TD)PD患者震颤的发生可能与广泛的灰质改变有关,主要涉及海马、丘脑束旁核、丘脑腹中间核、苍白球及小脑等,基于DTI的相关研究显示,TD患者的白质改变主要涉及下额枕束、上纵束、皮质脊髓束及左侧齿状核-红核-丘脑束等,这些区域与震颤症状的起源点及治疗点密切相关。本文就3D-T1WI及DTI的成像原理及其分析方法在TD中的研究进展作简要综述,为今后的研究提供依据和方向。
Parkinson's disease(PD)is a prevalent neurodegenerative condition characterized by progressive motor dysfunction that can lead to reduced daily activities,diminished quality of life,and eventual disability.To evaluate the underlying structural changes in PD patients,three dimensions T1-weighted imaging(3D-T1WI)and diffusion-tensor imaging(DTI)in structural MRI are utilized to provide a quantitative analysis of microstructural changes in gray matter and white matter,respectively.In recent years,research utilizing 3D-T1WI has implicated tremor in the tremor-dominant(TD)PD subtype,particularly in the hippocampus,parafascicular and ventral intermediate nucleus of the thalamus,pallidumand and cerebellum.DTI has revealed white matter changes in TD subtype patients mainly affecting the inferior fronto-occipital fasciculi,inferior longitudinal fasciculi,corticospinal tract and left dentatorubrothalamic tract,which closely related to the point of origin and treatment of tremor symptoms.This paper presents a review of the imaging principles and analysis methods utilized in the study of TD subtypes with 3D-T1WI and DTI,offering a foundation and guidance for future research.
作者
李倩
邱丽华
LI Qian;QIU Lihua(Department of Radiology,the First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China;Medical Imaging Center,the Second People's Hospital of Yibin,Yibin 644000,China;Neuroimaging Big Data Research Center,Clinical Medical Research and Transformation Center,Second People's Hospital of Yibin City-West China Yibin Hospital,Yibin 644000,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2023年第8期124-128,共5页
Chinese Journal of Magnetic Resonance Imaging
基金
国家重点研发计划(编号:2022YFC2009900、2022YFC2009901)
四川省医学会项目(编号:S19020)。
关键词
帕金森病
震颤
三维T1加权成像
扩散张量成像
灰质
白质
Parkinson's disease
tremor-dominant
three dimensions T1-weighted imaging
diffusion-tensor imaging
gray matter
white matter
