摘要
目的观察生活行为干预对肥胖2型糖尿病患者代谢功能的影响。方法选取2020年1月至2022年6月海口市龙华区辖区内的肥胖2型糖尿病患者作为研究对象,按照随机数字表法分为干预组和对照组,对照组实施常规药物治疗、基础饮食及运动疗法,干预组在常规治疗方式的基础上强化生活行为方式干预6个月。比较2组患者干预前后肥胖指标、血糖指标、血脂指标及胰岛功能指标变化;比较2组干预前后生活质量情况。结果本研究纳入的肥胖2型糖尿病中,对照组有效病例1487例,干预组有效病例1481例,2组患者年龄、性别、学历、病程等差异均无统计学意义(均P>0.05)。干预3、6个月后干预组患者腰围、体质指数(BMI)、空腹血糖(FBG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、空腹胰岛素(FINS)及胰岛素抵抗指数(HOMA-IR)均低于对照组,高密度脂蛋白胆固醇(HDL-C)及胰岛素分泌指数(HOMA-β)均高于对照组(P<0.05或P<0.01);干预组糖尿病生活质量量表(DQOL)评分低于对照组(P<0.01)。结论生活行为干预可以降低肥胖2型糖尿病患者BMI,调节血脂代谢水平,改善胰岛功能,提高其生活质量。
Objective To observe the effect of life behavior intervention on metabolic function in obese patients with type 2 diabetes mellitus(T2DM).Methods Obese patients with T2DM in Longhua District,Haikou City,from Jan-uary 2020 to June 2022 were selected and divided into intervention group and control group according to random number ta-ble.The control group received conventional drug therapy,basic diet and exercise therapy,and the intervention group add-ed intensive life behavior intervention for 6 months on the basis of conventional treatment.The changes of obesity indica-tors,blood glucose indicators,blood lipid indicators,islet function indicators,and quality of life of the two groups were compared before and after intervention.Results Among the obese patients with T2DM included in this study,there were 1487 effective cases in the control group and 1481 effective cases in the intervention group.There was no significant dif-ference in age,gender,educational background,and course of disease between the two groups(all P>0.05).After 3 and 6 months of treatment,waist circumference,body mass index(BMI),fasting blood glucose(FBG),2 hours postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c),triglyceride(TG),total cholesterol(TC),low density lipo-protein cholesterol(LDL-C),fasting insulin(FINS),and homeostatic model assessment for insulin resistance(HOMA-IR)in the intervention group were lower than those in the control group,while high density lipoprotein cholesterol(HDL-C)and homeostatic model assessment-β(HOMA-β)were higher than those in the control group(P<0.05 or P<0.01).The diabetes quality of life(DQOL)score of the intervention group was lower than that of the control group(P<0.05).Conclusion Life behavior intervention can reduce BMI in obese patients with T2DM,regulate blood lipid metabolism,improve islet function,and improve their quality of life.
作者
谭昶慧
万峰静
王毅
陈意灯
TAN Changhui;WAN Fengjing;WANG Yi;CHEN Yideng(Longhua District Maternal and Child Health Center,Haikou 571100,China;School of International Nursing,Hain-an Medical University;The Second Affiliated Hospital of Hainan Medical College;Longhua District Center for Disease Control and Prevention)
出处
《华南预防医学》
2023年第4期444-448,共5页
South China Journal of Preventive Medicine
基金
海南省卫生健康行业科研项目(21A200385)。
关键词
肥胖
2型糖尿病
生活行为干预
代谢功能
Obesity
Type 2 diabetes melllitus
Life behavior intervention
Metabolic function
