摘要
致病性大肠杆菌作为肠杆菌科成员和人兽共患病病原体之一,在一定条件下可通过多种途径引起人和动物感染并引发不同的大肠杆菌病病型。由于致病性大肠杆菌的血清型和毒力因子众多、耐药趋势严峻、存在生物被膜等因素导致大肠杆菌病的流行趋势复杂且疫苗研发困难,给国内外的畜禽养殖业带来一定的经济损失。高致病性岛(high-pathogenicity island,HPI)最早发现于耶尔森菌,被证实是其毒力表型所必需的基因组岛,为强毒力岛。由于细菌的水平转移机制让该毒力岛在其他肠杆菌科中被广泛检出。其中HPI毒力岛也在致病性大肠杆菌如肠出血性大肠杆菌(enterohemorrhage Escherichia coli,EHEC)、产志贺毒素大肠杆菌(shiga toxin-producing Escherichia coli,STEC)等中被大量检出,被证实影响致病性大肠杆菌毒力,参与致病性大肠杆菌铁元素摄取和介导宿主免疫反应等。为进一步了解HPI毒力岛在致病性大肠杆菌中的铁元素调控机理、致病特性、介导的细胞免疫反应和水平转移途径,现从HPI毒力岛结构、如何调控耶尔森菌素铁载体、HPI毒力岛致病性及调控细胞免疫反应、HPI毒力岛的水平转移进行概述,以期望为大肠杆菌的致病机理及大肠杆菌病的防控提供帮助。
Pathogenic Escherichia coli(E.coli)as a member of Enterobacteriaceae and one of the zoonotic pathogens,can cause human and animal infections through a variety of ways and cause different E.coli disease types under certain conditions.Due to the large number of serotypes and virulence factors,the severe trend of drug resistance,the existence of biofilm and other factors,the epidemic trend of colibacillosis is complex and the development of vaccines is difficult of pathogenic E.coli,which brings certain economic losses to the domestic and foreign livestock and poultry breeding industry.High-pathogenicity island(HPI)was first discovered in Yersinia,which was proved to be a genomic island necessary for its virulence phenotype.Due to the horizontal transfer mechanism of bacteria,the virulence island is widely detected in other Enterobacteriaceae.Among them,the HPI pathogenicity island was also detected in pathogenic E.coli such as enterohemorrhage E.coli(EHEC)and shiga toxin-producing E.coli(STEC),which was confirmed to affect the virulence of pathogenic E.coli,participate in the iron uptake of pathogenic E.coli and mediate the host immune response.In order to further understand the iron regulation mechanism,pathogenic characteristics,mediated cellular immune response and horizontal transfer pathway of HPI virulence island in pathogenic E.coli,this paper summarizes the structure of HPI virulence island,how to regulate Yersinia siderophore,the pathogenicity of HPI virulence island and its regulation of cellular immune response,and the horizontal transfer of HPI virulence island.It is expected to provide help for the pathogenic mechanism of E.coli and the prevention and control of E.coli disease.
作者
邹宏
罗干
陈玲
杜鹏飞
张乾义
杨承槐
田野
ZOU Hong;LUO Gan;CHEN Ling;DU Pengfei;ZHANG Qianyi;YANG Chenghuai;TIAN Ye(China Institute of Veterinary Drugs Control,Beijing 100081,China;Wanzhou Center for Animal Husbandry Industry Development,Chongqing 404100,China)
出处
《中国畜牧兽医》
CAS
CSCD
北大核心
2023年第8期3430-3437,共8页
China Animal Husbandry & Veterinary Medicine
基金
“十四五”国家重点研发计划项目《兽用生物制品标准物质研制》子课题“家畜细菌及支原体疫苗检验用菌种库建立”(2022YFD1800601-6)。
