摘要
急性肺损伤是一种具有高发病率和高死亡率的临床呼吸综合征,其发病机制复杂,治疗手段有限,给社会造成了严重的经济负担。动物模型能在个体水平、器官水平、细胞水平上反映疾病的发病机制及预防治疗方法的有效性和局限性。本文对急性肺损伤动物模型的构建方法进行了综述,以期为急性肺损伤动物模型的构建提供参考,便于科研工作者根据自身的实验需要,选择相应的实验方法构建急性肺损伤动物模型,进而研究不同因素导致的急性肺损伤的发病机制和预防治疗方法。
Acute lung injury is a kind of clinical respiratory syndrome with high morbidity and mortality.Its pathogenesis is complex and treatment is limited,which causes serious economic burden to society.Animal models can reflect the pathogenesis of disease and the effectiveness and limitations of prevention and treatment methods at the individual level,organ level and cell level.In this paper,the construction methods of animal models of acute lung injury were reviewed,in order to provide references for the construction of animal models of acute lung injury,so that researchers could choose appropriate experimental methods to build animal models of acute lung injury according to their own experimental needs,and then study the pathogenesis and prevention and treatment methods of acute lung injury caused by different factors.
作者
王佳佳
曲英敏
王莹
谢莹
WANG Jiajia;QU Yingmin;WANG Ying;XIE Ying(School of Electronic Information Engineering,Changchun University of Science and Technology,Changchun Jilin 130022)
基金
国家自然科学基金面上项目(62175020)
吉林省自然科学基金项目(20210101038JC)
吉林省教育厅项目(JJKH20220731KJ)。
关键词
急性肺损伤
动物模型
诱导因素
Acute lung injury
Animal model
Inducible factor
