摘要
目的检测Ⅰ~Ⅱ期非小细胞肺癌(NSCLC)患者手术切除组织中细胞周期蛋白依赖性激酶活化激酶组成因子1(MNAT1)蛋白表达,并探讨其意义。方法对南京市江宁医院2018年1月至2020年10月收治的96例Ⅰ~Ⅱ期NSCLC患者的临床资料进行回顾性分析,均实施手术切除,癌组织、癌旁组织均采用免疫组化法检测其MNAT1蛋白表达。患者均随访2年。结果癌组织MNAT1蛋白阳性表达率均高于癌旁组织(P<0.05);Ⅰ~Ⅱ期NSCLC患者术后1年复发率为30.21%,术后2年复发率为79.17%;癌组织MNAT1蛋白阳性表达与临床分期、淋巴结转移、分化程度、胸膜浸润、气道内播散、复发有关;术后2年生存与癌组织MNAT1蛋白阳性表达有关(P<0.05)。结论Ⅰ~Ⅱ期NSCLC患者癌组织中MNAT1蛋白阳性表达率高于癌旁组织,与临床分期、淋巴结转移、分化程度、胸膜浸润、气道内播散、复发及术后2年生存均有关。
Objective To detect the expression of menage a trois 1(MNAT1)in the surgically resected tissues of patients withⅠ-Ⅱstage non-small cell lung cancer(NSCLC)and to explore its significance.Methods The clinical data of 96 patients withⅠ-Ⅱstage NSCLC admitted to the Nanjing Jiangning hospital from January 2018 to October 2020 were reviewed and analyzed.All patients were surgically excised.Immunohistochemical method was used to detect the relative expression of MNAT1 protein.All of the patients were followed up for 2 years.Results The positive expression rate of MNAT1 protein in cancer tissues was higher than that in adjacent tissues(P<0.05).The 1-year recurrence rate of patients with stageⅠ-ⅡNSCLC was 30.21%,and the 2-year recurrence rate was 79.17%.The positive expression of MNAT1 protein in cancer tissues was related to clinical stage,lymph node metastasis,degree of differentiation,pleural infiltration,intraairway dissemination and recurrence.The 2-year survival was related to the positive expression of MNAT1 protein in cancer tissues.Conclusion The positive expression rate of MNAT1 protein in cancer tissues of patients with stageⅠ-ⅡNSCLC is higher than that in adjacent tissues,which is related to clinical stage,lymph node metastasis,degree of differentiation,pleural infiltration,intraairway dissemination,recurrence and 2-year survival.
作者
陈琳
唐桂莹
CHEN Lin;TANG Guiying(Department of Pathology of Nanjing Jiangning hospital,Nanjing,Jiangsu 210000 China)
出处
《国际检验医学杂志》
CAS
2023年第14期1752-1755,共4页
International Journal of Laboratory Medicine
