摘要
目的比较左乙拉西坦与奥卡西平在癫痫患儿中的治疗效果。方法选取2020年1月至12月烟台市北海医院收治的300例癫痫患儿作为研究对象,按照随机数字表法分为对照组(150例)和观察组(150例)。对照组采用奥卡西平治疗,观察组采用左乙拉西坦治疗。比较两组脑放电情况、治疗效果及不良反应发生情况。结果治疗2周后,两组脑放电总好转率比较,差异无统计学意义(P>0.05)。治疗8周后,两组脑放电总好转率高于治疗2周后,且观察组高于对照组(P<0.05)。观察组治疗总有效率高于对照组(P<0.05)。观察组不良反应总发生率低于对照组(P<0.05)。结论左乙拉西坦与奥卡西平治疗儿童癫痫的短期效果相近,但左乙拉西坦远期治疗效果更为显著,可有效改善脑部痫样放电,且不良反应较少。
Objective To compare the therapeutic effect of Levetiracetam and Oxcarbazepine in children with epilepsy.Methods A total of 300 children with epilepsy admitted to Yantai Beihai Hospital from January to December 2020 were selected as the study objects and divided into the control group(150 cases)and the observation group(150 cases)according to the random number table method.The control group was treated with Oxcarbazepine,and the observation group was treated with Levetiracetam.The cerebral discharge,therapeutic effect and adverse reactions were compared between the two groups.Results After 2 weeks of treatment,there was no significant difference in the total improvement rate of cerebral discharge between the two groups(P>0.05).After 8 weeks of treatment,the total improvement rate of cerebral discharge in both groups was higher than that after 2 weeks of treatment,and that in the observation group was higher than that in the control group(P<0.05).The total effective rate of the observation group was higher than that of the control group(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion The short-term effects of Levetiracetam and Oxcarbazepine in the treatment of children with epilepsy are similar.But the long-term effect of Levetiracetam is more significant,which can effectively improve the epileptiform dis charge in the brain,and the adverse reactions are fewer.
作者
刘晓杰
LIU Xiaojie(Department of Pharmacy,Yantai Beihai Hospital,Shandong Province,Yantai 265701,China)
出处
《妇儿健康导刊》
2023年第13期114-116,共3页
JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE
关键词
左乙拉西坦
奥卡西平
癫痫
痫样放电
儿童
Levetiracetam
Oxcarbazepine
Epilepsy
Epileptiform discharge
Children
