摘要
目的探讨维持性腹膜透析患者发生高尿酸血症的影响因素。方法回顾性分析2015年1月至2018年12月宁夏回族自治区人民医院肾脏内科的74例腹膜透析患者的临床资料,依据血尿酸水平分为高尿酸血症组39例和血尿酸正常组35例。比较两组患者的实验室及临床指标,影响因素分析采用logistic回归分析。结果尿酸正常组糖尿病发生率低于高尿酸血症组,差异有统计学意义(P<0.05);两组患者年龄、性别、高血压发生率、冠心病发生率比较,差异无统计学意义(P>0.05)。尿酸正常组血浆白蛋白(Alb)、前白蛋白(pAlb)、血尿素氮(BUN)、血肌酐(Scr)、血磷(P)、甲状旁腺素(iPTH)、甘油三酯(TG)水平均低于高尿酸血症组,差异有统计学意义(P<0.05)。尿酸正常组高密度脂蛋白(HDL-C)水平高于高尿酸血症组,差异有统计学意义(P<0.05)。两组患者血红蛋白(Hb)、总蛋白(TP)、总胆红素(TBil)、碱性磷酸酶(ALP)、β_(2)-微球蛋白(β_(2)-MG)、血钙(Ca)、超敏C反应蛋白(hs-CRP)、维生素D(VD)、红细胞沉降率(ESR)、胆固醇(TC)、低密度脂蛋白(LDL-C)水平比较,差异无统计学意义(P>0.05)。多因素logistic回归分析显示,TG(OR=3.650,95%CI:1.072~12.431,P<0.05)是腹膜透析患者发生高尿酸血症的独立危险因素,HDL-C(OR=0.066,95%CI:0.005~0.878,P<0.05)是腹膜透析患者发生高尿酸血症的保护因素。结论维持性腹膜透析患者高尿酸血症的发生率较高,TG是维持性腹膜透析患者发生高尿酸血症的独立危险因素,HDL-C是其发生高尿酸血症的保护因素,应高度重视维持性腹膜透析患者血尿酸的管理。
Objective To investigate the influencing factors of hyperuricemia in maintenance peritoneal dialysis patients.Methods The clinical data of 74 peritoneal dialysis patients from January 2015 to December 2018 were retrospectively selected from the Department of Nephrology,People's Hospital of the Ningxia Hui Autonomous Region,they were divided into 39 cases in the hyperuricemia group and 35 cases in the normal blood uric acid group according to the serum uric acid level.The laboratory and clinical data of the two groups were compared,and the influencing factors were analyzed by logistic regression.Results The incidence of diabetes in normal uric acid group was lower than that in hyperuricemia group,and the difference was statistically significant(P<0.05).There were no significant differences in age,gender,incidence of hypertension and incidence of coronary heart disease between the two groups(P>0.05).The levels of plasma albumin(Alb),prealbumin(pAlb),blood urea nitrogen(BUN),serum creatinine(Scr),serum phosphorus(P),parathyroid hormone(iPTH)and triglyceride(TG)in the normal uric acid group were lower than those in the hyperuricemia group,and the differences were statistically significant(P<0.05).The level of high density lipoprotein cholesterol(HDL-C)in the normal uric acid group was higher than that in the hyperuricemia group,and the difference was statistically significant(P<0.05).There were no significant differences in the hemoglobin(Hb),total protein(TP),total bilirubin(TBil),alkaline phosphatase(ALP),β_(2)-microglobulin(β_(2)-MG),calcium(Ca),high-sensitivity C-reactive protein(hs-CRP),vitamin D(VD),erythrocyte sedimentation rate(ESR),blood cholesterol(TC),low density lipoprotein cholesterol(LDL-C)between the two groups(P>0.05).The result of multifactorial logistic regression analysis showed that TG(OR=3.650,95%CI:1.072-12.431,P<0.05)was an independent risk factor for hyperuricemia in peritoneal dialysis patients.HDL-C(OR=0.066,95%CI:0.005-0.878,P<0.05)was a protective factor for hyperuricemia in peritoneal dialysis patients(P<0.05).Conclusion The incidence of hyperuricemia in peritoneal dialysis patients is high.TG is an independent risk factor for the development of hyperuricemia in peritoneal dialysis patients,and HDL-C is a protective factor for the development of hyperuricemia in peritoneal dialysis patients.Therefore,the management of serum uric acid in peritoneal dialysis patients should be given high priority.
作者
张秀梅
邹璐荣
马丹娜
韩学卫
鄂静
王慧
郑亚莉
ZHANG Xiumei;ZOU Lurong;MA Danna;HAN Xuewei;E Jing;WANG Hui;ZHENG Yali(Department of Nephrology,People's Hospital of Autonomous Region Affiliated to Ningxia Medical University,People's Hospital of Ningxia Hui Autonomous Region,Ningxia Hui Autonomous Region,Yinchuan 750021,China)
出处
《中国当代医药》
CAS
2023年第20期87-91,共5页
China Modern Medicine
关键词
腹膜透析
血尿酸
血脂
影响因素
Peritoneal dialysis
Serum uric acid
Blood fat
Influencing factors
