摘要
目的了解血浆proBDNF水平在原发性干燥综合征(pSS)患者伴抑郁症状中的作用,并对相关因素进行探讨,为早期干预提供参考。方法采用自制一般情况调查表及PHQ-9量表对42例pSS患者及81例健康对照进行调查,并对42例pSS患者采用应对方式问卷(SCSQ)、社会支持评定量表(SSRS)进行调查和评分,欧洲抗风湿病联盟pSS病情活动度量表(ESSDAI)评估pSS疾病活动度。取得知情同意后抽取外周血3~5 mL,检测血浆中proBDNF的水平。结果pSS伴随抑郁症状患者血浆proBDNF水平升高最为明显(P<0.05),较少的社会支持是pSS伴随抑郁症状的危险因子。结论proBDNF可能参与了pSS伴随抑郁症状的发病机制,pSS患者合并抑郁症状时需要更多的社会支持。
Objective To study the role of plasma proBDNF level in patients with primary Sjogren's syndrome(pSS)with depressive symptoms,and to explore related factors,so as to provide evidence for early intervention.Methods A total of 42 pSS patients and 81 healthy controls were investigated with self-made general information questionnaire and PHQ-9 scale,and 42 pSS patients were investigated and scored with Coping style questionnaire(SCSQ)and social support rating scale(SSRS).European Antirheumatic Association pSS Disease Activity Scale(ESSDAI)was used to evaluate the disease activity of pSS.After informed consent was obtained,3-5 ml peripheral blood was collected to detect the level of proBDNF.Results The increase of plasma proBDNF level in patients with pSS complicated with depressive symptoms was the most significant(P<0.05),and less social support was a risk factor.Conclusion ProBDNF may be involved in the pathogenesis of pSS with depressive symptoms,and these patients need more social support.
作者
冯大莺
陈华英
潘虹英
杨芝兰
晏姗
周莉
FENG Daying;CHEN Huaying;PAN Hongying;YANG Zhilan;YAN Shan;ZHOU Li(Dept.of Rheumatology and Immunology,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032;The Mental Health Center Affiliated to Kunming Medical University,Kunming Yunnan 650224;Institute of Biomedical Engineering,Kunming Medical University,Kunming Yunnan 650500,China)
出处
《昆明医科大学学报》
CAS
2023年第6期54-58,共5页
Journal of Kunming Medical University
基金
国家自然科学基金资助项目(81960806)
云南省科技厅-昆明医科大学应用基础研究联合专项基金重点项目[2019FE001(-001)]
云南省教育厅科学研究基金资助项目(2022J0253)。
