摘要
阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种常见的睡眠障碍,由睡眠期间出现的上气道塌陷和阻塞引起,伴有打鼾、白天嗜睡及睡眠结构紊乱,与心血管疾病、代谢紊乱、糖尿病、认知功能障碍及肿瘤密切相关。OSAHS患病率较高,增加了社会经济负担,因此加强其早期诊断和治疗具有重要意义。微小核糖核酸(miRNA)是一种非编码的小RNA分子,可通过调控相关靶基因的表达发挥多种重要生物学功能。近年研究显示,miRNA可作为高血压病、冠心病、糖尿病和肿瘤早期诊断的生物标志物,也有望用于OSAHS及相关并发症的早期诊断、病情评估及治疗。本文综述miRNA在OSAHS及其并发症中的作用研究进展。
Obstructive sleep apnea hypopnea syndrome(OSAHS)is a common sleep disorder,which is caused by collapse and obstruction of upper airway during sleep,accompanied by snoring,daytime drowsiness and sleep structure disorder.OSAHS is closely related to cardiovascular disease,metabolic disorder,diabetes,cognitive impairment and tumors.The prevalence rate of OSAHS is relatively high,which significantly increases the social and economic burden.Therefore,early diagnosis and treatment of OSAHS is necessary.miRNA is a non-coding small RNA molecule,which can play important role in a variety of important biological functions by regulating the expression of target genes.In recent years,some studies indicated that miRNA could be used as a biomarker for early diagnosis of hypertension,coronary heart disease,diabetes and tumors.Recently,a large number of studies showed that miRNA can be used in diagnosis,assessment,and therapeutic target of OSAHS with its complications.This review summarizes the research progress on the role of miRNA in OSAHS with its complications.
作者
黄家容
张凤蕊
平芬
Huang Jia-Rong;Zhang Feng-Rui;Ping Fen(Graduate School,Hebei North University,Zhangjiakou,Hebei 075000,China;Department of Geriatric Respiratory Medicine,Hebei General Hospital,Shijiazhuang,Hebei 050051,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2023年第6期735-741,共7页
Medical Journal of Chinese People's Liberation Army
基金
河北省2019年政府资助临床医学优秀人才培养项目。
