摘要
激素性股骨头坏死(steroid-induced avascular necrosis of the femoral head,SANFH)是临床上常见的疑难杂症,其致残率高、预后差的特点,严重威胁了人类的健康。SANFH的发病机制十分复杂,但现在越来越多的研究表明,大量的糖皮质激素会导致骨组织细胞的线粒体功能异常,发生氧化应激、线粒体自噬、以及线粒体动力学改变,导致细胞受损或死亡,进而导致股骨头内骨代谢失衡、血流异常,加速了SANFH的发生发展。中药有着安全性高、副作用少等优点,在SANFH的治疗中有着良好的疗效。中药复方、单味中药和中药活性成分可以通过直接或间接地调控相应的信号通路中关键分子表达,多靶点改善线粒体功能,显著防治SANFH的发生发展,受到了学者们的广泛关注。该文综述了SANFH与线粒体功能之间的关系,以及中药通过调控线粒体功能来防治SANFH的作用机制,以期为临床应用中药调控线粒体功能来治疗SANFH提供一定的思路与方法。
Steroid-induced avascular necrosis of the femoral head(SANFH)is a common and intractable disease with high disability rate and poor prognosis,which is a serious threat to human health.The pathogenesis of SANFH is very complex,but more and more studies have shown that high doses of glucocorticoids would cause abnormal mitochondrial function of bone tissue cells,oxidative stress,mitochondrial autophagy,and altered mitochondrial dynamics,resulting in cell damage or death.These would then lead to imbalance of bone metabolism and abnormal blood flow in the femoral head,accelerating the occurrence and development of SANFH.With advantages of high safety and low side effects,Chinese medicinals have a good effect in the treatment of SANFH.Compound formulas,single Chinese medicinal and active ingredients of Chinese medicinals can directly or indirectly regulate the expression of key molecules in the corresponding signaling pathways,improve mitochondrial function at multiple targets,and significantly prevent the occurrence and development of SANFH,which have attracted wide attention from scholars.This paper reviews the relationship between SANFH and mitochondrial function,and the mechanism of Chinese medicinals preventing and treating SANFH by modulating mitochondrial function,in order to provide certain ideas and methods for the treatment of SANFH by applying Chinese medicinals to modulate mitochondrial function.
作者
胡康一
曹林忠
万超超
尚征亚
杨小瑞
张勇杰
HU Kangyi;CAO Linzhong;WAN Chaochao;SHANG Zhengya;YANG Xiaorui;ZHANG Yongjie(Gansu University of Chinese Medicine;Geriatric orthopedics,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,Gansu,China)
出处
《中国临床药理学与治疗学》
CAS
CSCD
2023年第6期688-696,共9页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
国家自然科学基金项目(81860859,82160915)
甘肃中医药大学研究生创新基金(2023CX06)。
