摘要
目的探讨磷酸肌酸钠治疗心肌炎的临床疗效及对心肌酶谱和炎症因子的影响。方法选取2019年2月至2020年2月本院收治的92例心肌炎患者作为研究对象,随机分为对照组和观察组,各46例。对照组采用常规治疗,观察组采用磷酸肌酸钠治疗,比较两组临床疗效及治疗前后心肌酶指标[天冬氨酸转氨酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶同工酶(CK-MB)]、炎症因子指标[血清超敏C反应蛋白(hs-CRP)、可溶性细胞间黏附分子1(sICAM-1)、肿瘤坏死因子-α(TNF-α)]。结果观察组治疗总有效率为91.30%,高于对照组的76.09%,差异有统计学意义(P<0.05)。治疗前,两组AST、LDH及CK-MB水平比较差异无统计学意义;治疗后,两组AST、LDH及CK-MB水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组的hs-CRP、sICAM-1及TNF-α水平比较差异无统计学意义;治疗后,两组的hs-CRP、sICAM-1及TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论采用磷酸肌酸钠治疗心肌炎患者,能有效提升临床疗效,有效改善患者的心肌酶指标及炎症因子指标水平,值得临床推广并应用。
Objective To investigate the therapeutic effect of sodium creatine phosphate in the treatment of myocarditis and its effect on myocardial enzymes and inflammatory factors.Method A total of 92 patients with myocarditis admitted to our hospital from February 2019 to February 2020 were selected as the research subject,and they were randomly divided into control group and observation group,with 46 cases in each group.The control group was treated with conventional treatment,and the observation group was treated with sodium creatine phosphate,and the clinical efficacy,the levels of myocardial enzyme indexes(aspartate aminotransferase[AST],lactate dehydrogenase[LDH],creatine kinase isoenzyme[CK-MB]),and the inflammatory factors(serum hypersensitivity C-reactive protein[hs-CRP],soluble intercellular adhesion molecule 1[sICAM-1],tumor necrosis factor-α[TNF-α])before and after treatment were compared between two groups.Results The total effective rate of treatment in the observation group was 91.30%,which was higher than 76.09%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of AST,LDH and CK-MB between the two groups;after treatment,the levels of AST,LDH and CK-MB in both groups were lower than those before treatment,and the observation group was lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of hs-CRP,sICAM-1 and TNF-αbetween the two groups;after treatment,the levels of hs-CRP,sICAM-1 and TNF-αin two groups were lower than those before treatment,and the observation group was lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion The use of sodium phosphocreatine in the treatment of patients with myocarditis can effectively improve the clinical efficacy and effectively improve the myocardial enzyme indexes and inflammatory factor indexes of patients,which is worthy of clinical promotion and application.
作者
张艳丽
ZHANG Yanli(Department of Pharmacy,Donggang Central Hospital,Dandong,Liaoning,118300,China)
出处
《当代医学》
2022年第32期62-65,共4页
Contemporary Medicine
基金
沈阳市科技局项目(RC19085563)。
关键词
磷酸肌酸钠
心肌炎
临床疗效
心肌酶水平
Sodium creatine phosphate
Myocarditis
Clinical efficacy
Myocardial enzyme indexs
