摘要
目的探讨中性粒细胞与淋巴细胞比值(NLR)与C反应蛋白/白蛋白比值(CAR)在大肠癌围术期感染患者中的表达及其检测价值。方法选取2019年10月至2021年10月于四川护理职业学院附属医院诊治的102例大肠癌患者为观察组,另取同期体检健康者60名为对照组,比较两组的CAR和NLR水平;根据围术期是否发生感染将观察组分为感染组与未感染组,比较两组一般资料和CAR和NLR水平;随访12个月,根据患者是否死亡将感染患者分为死亡组和存活组,采用ROC曲线分析CAR、NLR及两者联合检测对大肠癌患者围术期感染和预后的诊断价值。结果观察组的CAR、NLR水平高于对照组,差异有统计学意义(P<0.05);感染组的C⁃反应蛋白(CRP)、白细胞(WBC)、中性粒细胞和淋巴细胞以及CAR、NLR水平均高于未感染组,白蛋白(Alb)水平低于未感染组,差异有统计学意义(P<0.05);死亡组的CAR和NLR水平均高于存活组,差异有统计学意义(P<0.05);CAR和NLR联合诊断大肠癌患者围术期感染的AUC为0.915(95%CI:0.843~0.961),且联合诊断的AUC高于单一诊断(P<0.05);CAR和NLR联合评估大肠癌围术期感染患者预后的AUC为0.900(95%CI:0.766~0.971),且联合评估的AUC高于单一评估(P<0.05)。结论NLR和CAR可有效诊断大肠癌围术期感染,并预测感染患者预后。
Objective To explore the expression and detection value of neutrophils to lymphocytes ratio(NLR)and C⁃reactive protein/albumin ratio(CAR)in patients with colorectal cancer and perioperative infection.Methods A total of 102 patients with colorectal cancer treated in Affiliated Hospital of Sichuan Nursing Vocational College were enrolled as the observation group between October 2019 and October 2021,while 60 healthy controls during the same period were enrolled as the control group.CAR and NLR were compared between the two groups.According to presence or absence of perioperative infection,patients in the observation group were divided into the infection group and the non⁃infection group,general data,CAR and NLR in the two groups were compared.After 12 months of follow⁃up,patients in infection group were divided into the death group and the survival prognosis group according to presence or absence of death.The diagnostic value of CAR,NLR and combined detection for perioperative infection and prognosis was analyzed by ROC curves.Results CAR and NLR in the observation group were higher than those in the control group(P<0.05).The levels of C⁃reactive protein(CRP),white blood cell(WBC),neutrophils,lymphocytes,CAR and NLR in the infection group were higher than those in the non⁃infection group,while albumin(Alb)level was lower than that in the non⁃infection group(P<0.05).CAR and NLR in the death group were higher than those in the survival group(P<0.05).The AUC of CAR combined with NLR in the diagnosis of perioperative infection was 0.915(95%CI:0.843~0.961),greater than that of single indicator(P<0.05).The AUC of CAR combined with NLR for assessing prognosis of patients with perioperative infection was 0.900(95%CI:0.766~0.971),greater than that of single indicator(P<0.05).Conclusion NLR and CAR can effectively diagnose perioperative infection and predict prognosis of patients with colorectal cancer.
作者
王勇
何能
刘佳
刘伟
郑祖文
WANG Yong;HE Neng;LIU Jia;LIU Wei;ZHENG Zuwen(Department of General Surgery,Affiliated Hospital of Sichuan Nursing Vocational College(Sichuan Third People's Hospital),Chengdu Sichuan,China,610000)
出处
《分子诊断与治疗杂志》
2023年第5期805-808,812,共5页
Journal of Molecular Diagnostics and Therapy
基金
四川省科技厅课题(2017TD0029)。
