摘要
目的探讨醒脑通窍汤对脑梗死恢复期患者血液流变学及认知功能的影响。方法方便选取2021年1月—2022年1月在福建中医药大学附属人民医院脑病科、福建师范大学医院神经内科治疗的72例脑梗死恢复期患者为研究对象,随机分为两组,对照组使用常规西医治疗,观察组在此基础上,加用醒脑通窍汤,疗程共8周,对比两组的临床疗效、血液流变学指标、血小板参数、神经功能缺损指标、认知及运动指标。结果观察组治疗有效率为94.44%(34/36),高于对照组的76.47%(26/36),差异有统计学意义(χ^(2)=6.400,P<0.05);观察组治疗后血浆黏度、全血(高/低)切黏度、红细胞压积、花生四烯酸、二磷酸腺苷均低于对照组,差异有统计学意义(t=6.864、13.081、6.321、5.418、7.640、18.958,P<0.05);观察组治疗后血小板计数、血小板压积高于对照组,平均血小板体积、血小板分布宽度低于对照组,差异有统计学意义(t=2.869、4.243、4.586、2.539,P<0.05);观察组治疗后NHISS评分低于对照组,BI指数、MoCA评分、FMA评分明显高于对照组,差异有统计学意义(t=6.101,4.219、2.282、3.698,P<0.05)。结论醒脑通窍汤对脑梗死恢复期有显著疗效,可改善血液流变学,改善血小板参数,明显减轻神经功能缺损,促进认知、肢体等功能的恢复,提高生活质量。
Objective To investigate the effects of Xingnao Tongqiao decoction on blood rheology and cognitive function in patients recovering from cerebral infarction.Methods 72 patients recovering from cerebral infarction treated at the Department of Encephalopathy,Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine and the Department of Neurology,Fujian Normal University Hospital from January 2021 to January 2022 were conveniently selected as the research subjects,and randomly divided into two groups.The control group was treated with conventional Western medicine,and the observation group was treated with the addition of Xingnao Tongqiao decoction for a total of 8 weeks.The clinical efficacy,blood rheology indexes,platelet parameters,neurological deficit indexes,cognitive and motor indexes of the two groups were compared.Results The effective rate of treatment in the observation group was 94.44%(34/36),which was higher than 76.47%(26/36)in the control group,and the difference was statistically significant(χ^(2)=6.400,P<0.05).Plasma viscosity,whole blood(high/low)cut viscosity,red blood cell pressure,arachidonic acid,and adenosine diphosphate in the observation group were lower than those in the control group after treatment,and the difference was statistically significant(t=6.864,13.081,6.321,5.418,7.640,18.958,P<0.05).The platelet count and platelet pressure volume in the observation group were higher than those in the control group after treatment,and the mean platelet volume and platelet distribution width were lower than those in the control group,and the difference was statistically significant(t=2.869,4.243,4.586,2.539,P<0.05).The NHISS score in the observation group was lower than that in the control group after treatment,and the BI index,MoCA score,and FMA score were significantly higher than those in the control group,and the difference was statistically significant(t=6.101,4.219,2.282,3.698,P<0.05).Conclusion Xingnao Tongqiao decoction has significant efficacy in the recovery period of cerebral infarction,improving blood rheology,platelet parameters,significantly reducing neurological deficits,promoting the recovery of cognitive and limb functions,and improving the quality of life.
作者
阮甦
林昱
倪财锋
RUAN Su;LIN Yu;NI Caifeng(Department of Encephalopathy,Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian Province,350004 China;Department of Neurology,Fujian Normal University Hospital,Fuzhou,Fujian Province,350007 China)
出处
《中外医疗》
2023年第11期184-188,共5页
China & Foreign Medical Treatment
关键词
脑梗死恢复期
醒脑通窍汤
血液流变学
神经功能缺损
认知功能
Recovery period of cerebral infarction
Xingnao Tongqiao decoction
Blood rheology
Neurological deficits
Cognitive function
