摘要
The integrated lipopeptide(RVA)/gene complexes are fabricated with bi-directional regulation on tumor cells and micro-environment.After self-assembling and target coating modification,the poly(γ-glutamic acid)(γ-PGA)/RVA nano-vectors can sequentially respond to pH&redox stimuli,and guarantee efficient therapeutic gene delivery and control release of all-trans retinoic acid.The design provides a facile but promising strategy to treat refractory cancers.
基金
financially supported by National Natural Science Foundation of China(NSFC,Nos.81873921 and 51903174)
Sino-German Cooperation Group Project(No.GZ1512)
China Postdoctoral Science Foundation(No.2021M702772)
Chengdu Science and Technology Program(No.2020-GH02-00007-HZ)
Sichuan University Postdoctoral Interdisciplinary Innovation Startup Foundation and the Fundamental Research Funds for Central Universities(No.2021SCU12070)。
