摘要
目的分析LEEP与宫颈冷刀锥切术治疗宫颈上皮内瘤变(CIN)的临床效果及对患者生育功能的影响。方法选择108例CIN患者,随机分为LEEP组(n=52)与宫颈冷刀锥切术(CKC,n=56)组,比较两组转阴率、复发率、妊娠率、妊娠结局、宫颈机能不全发生率。结果LEEP组、CKC组高危型HPV转阴率、CIN转阴率、复发率、术后24个月内妊娠率经统计学分析,呈相近趋势,P>0.05。LEEP组、CKC组妊娠例数分别是42例、47例,所有妊娠妇女均接受随访,比较两组妊娠妇女的妊娠结局显示:LEEP组早产率高于CKC组(P<0.05);LEEP组宫颈机能不全率(3.85%)、CKC组宫颈机能不全率(5.36%);LEEP组、CKC组流产率、新生儿窒息率经统计学分析,呈相近趋势,P>0.05。结论将LEEP和CKC应用于CIN的治疗中,临床效果相近;但与LEEP比较,CKC术后宫颈机能不全率更高。
Objective To analyze the clinical effect of LEEP and cervical cold knife conization in the treatment of cervical intraepithelial neoplasia(CIN)and its effect on reproductive function.Methods 108 patients with CIN were randomly divided into LEEP group(n=52)and cervical cold knife conization group(CKC,n=56).The negative conversion rate,recurrence rate,pregnancy rate,pregnancy outcome and incidence of cervical incompetence were compared between the 2 groups.Results The negative rate of high-risk HPV,CIN,recurrence rate and pregnancy rate within 24 months after operation in LEEP group and CKC group showed similar trend(P>0.05).The number of pregnancies in LEEP group and CKC group was 42 and 47 respectively.All pregnant women were followed up.The comparison of pregnancy outcomes between the 2 groups showed that the rate of premature delivery in LEEP group was higher than that in CKC group(P<0.05).The rate of cervical incompetence in LEEP group(3.85%)and the rate of cervical incompetence in CKC group(5.36%).The rate of abortion and neonatal asphyxia in LEEP group and CKC group showed a similar trend after statistical analysis,P>0.05.Conclusion The application of LEEP and CKC in the treatment of CIN can obtain significant clinical effects and improve the quality of life of patients;However,compared with LEEP,the rate of cervical insufficiency after CKC is higher.
作者
刘彩霞
郭宝芝
周新华
刘爱珍
方明珠
蔡海瑜
LIU Caixia;GUO Baozhi;ZHOU Xinhua(Zhengzhou Maternal and Child Health Care Hospital,Zhengzhou,450041)
出处
《实用癌症杂志》
2023年第6期1000-1002,共3页
The Practical Journal of Cancer
关键词
LEEP
宫颈冷刀锥切术
宫颈上皮内瘤变
生育功能
LEEP
Cold knife conization of cervix
Cervical intraepithelial neoplasia
Reproductive function
