摘要
目的探讨自拟清郁和降汤治疗肝胃郁热型反流性食管炎(RE)患者的临床效果。方法选取2021年1月至2022年4月四川省自贡市第一人民医院收治的98例RE患者,采用随机数字表法将其分为对照组、观察组,各49例。对照组以常规西药治疗,观察组增加自拟清郁和降汤治疗。两组均以14 d为1个疗程,共治疗3个疗程。比较两组疗效,两组治疗前后中医症候积分、食管动力学,记录不良反应发生情况。结果治疗后,两组反酸烧心、脘腹胀满、嗳气早饱、食欲不振、舌红苔黄积分低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组食管括约肌压力、下食管括约肌压力、食管远端收缩积分高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组临床疗效优于对照组,差异有统计学意义(P<0.05)。两组治疗期间总发生率比较,差异无统计学意义(P>0.05)。结论自拟清郁和降汤治疗肝胃郁热型RE效果显著,可有效改善临床症状和食管动力,安全性较高。
Objective To investigate the clinical effects of self-made Qingyu Hejiang Decoction Tang in treating patients with liver and stomach stagnation-heat type of reflux esophagitis(RE).Methods Ninety-eight cases of RE patients admitted to Zigong First People’s Hospital,Sichuan Province from January 2021 to April 2022 were selected and divided into control and observation groups using the random number table method,with 49 cases in each group.The control group was treated with conventional western medicine,while the observation group was treated with the addition of self-made Qing Yu and Hejiang Decoction.Both groups were treated with 14 d as a course of treatment,and a total of three courses of treatment were given.The efficacy of the two groups was compared,the traditional Chinese medicine symptom score and esophageal kinetics before and after treatment in both groups,and the occurrence of adverse reactions was recorded.Results After the treatment,the points of acid reflux and heartburn,abdominal distension and fullness,belching and early satiety,loss of appetite,and red tongue with yellow coating in both groups were lower than those before treatment,while those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the esophageal sphincter pressure,lower esophageal sphincter pressure,and distal esophageal contraction points in both groups were higher than before treatment,while those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The clinical efficacy of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).The difference was not statistically significant when comparing the total incidence rate during treatment between the two groups(P>0.05).Conclusion The self-made Qingyu Hejiang Decoction is effective in treating RE with liver and stomach stagnation and heat,and can effectively improve clinical symptoms and esophageal dynamics with high safety.
作者
刘洁
朱琦
陈新
白少玉
任登杰
LIU Jie;ZHU Qi;CHEN Xin;BAI Shaoyu;REN Dengjie(Department of Integrated Traditional Chinese Medicine and Western Medicine,Zigong First People’s Hospital,Sichuan Province,Zigong643000,China)
出处
《中国医药导报》
CAS
2023年第13期100-103,共4页
China Medical Herald
基金
四川省中医药管理局中医药科研课题(2020LC110)。
关键词
反流性食管炎
自拟清郁和降汤
肝胃郁热型
食管动力学
Reflux esophagitis
Self-made Qingyu Hejiang Decoction
Liver and stomach stagnution-heat type
Esophageal dynamics
