摘要
基质细胞衍生因子1(SDF-1)及其受体趋化因子受体-4(CXCR4)组成的生物轴与多种信号通路有着密切的联系,二者在人体多种细胞与组织中均有表达,且两者结合参与多种炎症和疾病的发生、发展过程,其具体作用在骨相关疾病的实验及临床研究中均得到证实。中医理论认为“肾主骨”,肾与骨的关系非常密切,肾脏亏虚,则骨失所养,筋失所依,进而诱发骨类疾病的发生。除此之外肝、脾二脏在骨类疾病的发生中也扮演着重要角色,肝脏亏虚,筋失所养,筋有束骨之功,骨弱则筋病,筋废则骨病;脾主肌肉,肌肉与骨骼协同发挥运动功能。中医药对于骨类疾病的治疗有着独特优势,可通过补肾、健脾、调肝等中医不同治法对骨类疾病进行治疗,从而达到一定效果。该文基于SDF-1/CXCR4信号通路对中医药治疗骨类相关疾病(骨质疏松症、骨性关节炎、骨折、椎间盘退变、强直性脊柱炎)的实验及临床研究进展进行综述。
The biological axis of stromal cell-derived factor-1(SDF-1)and its receptor chemokine receptor-4(CXCR4)is closely related to various signaling pathways,and both of them are expressed in a variety of cells and tissues in the human body,both of them are involved in the occurrence and development of many kinds of inflammation and diseases,and their specific effects have been confirmed in the experimental and clinical studies of bone-related diseases.According to the theory of traditional Chinese medicine,“the kidney dominates the bone”,the relationship between the kidney and the bone is very close.In addition,the liver and spleen also play an important role in the occurrence of bone diseases,liver deficiency,muscle loss,muscle has the function of binding the bone,weak bone is muscle disease,muscle waste is bone disease;spleen main muscle,muscle and bone coordinated exercise function.Traditional Chinese medicine has unique advantages in the treatment of bone diseases,such as tonifying the kidney,strengthening the spleen and regulating the liver and other traditional Chinese medicine treatment of bone diseases,so as to achieve a certain effect.Based on SDF-1 CXCR4 signaling pathway,this article reviews the experimental and clinical research progress of traditional Chinese medicine in the treatment of bonerelated diseases(osteoporosis,osteoarthritis/osteodystrophy,fracture,intervertebral disc degeneration,ankylosing spondylitis).
作者
付夜平
杨芳
孙鑫
FU Yeping;YANG Fang;SUN Xin(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China)
出处
《辽宁中医药大学学报》
CAS
2023年第4期157-161,共5页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然科学基金项目(81973719,82104709)
辽宁省科技厅项目(2019-ZD-0958)
沈阳市中青年科技创新人才计划项目(RC200160)
辽宁省“百千万人才工程”项目(2020921100)。
