摘要
信号转导及转录激活因子(STAT)家族参与免疫、炎症反应、细胞凋亡、肿瘤发生以及多种细胞生理过程。其中IL-6/JAK/STAT和IL-4/JAK/STAT信号通路在多种恶性肿瘤细胞中被激活,抑制STAT3异常激活成为抗肿瘤药物研发的重要靶标。本文对STAT家族的生物学功能及其与肿瘤的关系,以STAT家族分子为靶点的药物研发的进展作一综述。
The signal transducer and activator of transcription(STAT)family is involved in immunity,inflammation,apoptosis,oncogenesis,and a variety of cellular physiological processes.The activation of IL-6/JAK/STAT and IL-4/JAK/STAT signaling pathways play an important role in a variety of malignant tumor cells and then the inhibition of abnormal activation of STAT3 has become a key target for the development of anti-tumor drugs.This article reviews the biological functions of the STAT family and their relationship with tumors,as well as the development of some drugs targeting STAT family molecules.
作者
钟文韬
张琦
李方琪
严婧
梁作文
李晶
Zhong Wentao;Zhang Qi;Li Fangqi;Yan Jing;Liang Zuowen;Li Jing(The First Hospital of Jilin University,Changchun 130021;The Second Hospital of Jilin University,Changchun 130021;Department of Andrology,the First Hospital of Jilin University,Changchun 130021;Department of Pharmacology,College of Basic Medical Sciences,Jilin University,Changchun 130021)
出处
《国际老年医学杂志》
2023年第3期347-350,共4页
International Journal of Geriatrics
基金
吉林省科技发展计划项目(20210101320JC)
吉林省发改委产业技术研究与开发项目(2020C034-2)。
关键词
信号转导与转录激活因子
肿瘤
药物研发
Signal transducer and activator of transcription
Tumor
Drug development
