摘要
目的分析聚甲酚磺醛溶液宫颈局部用药治疗慢性子宫颈炎糜烂样改变的临床效果。方法96例慢性子宫颈炎糜烂样改变患者,随机分为对照组和研究组,每组48例。对照组患者口服盐酸左氧氟沙星+宫炎平片治疗,研究组患者在对照组基础上联合聚甲酚磺醛溶液局部用药。对比两组患者临床疗效,临床症状改善时间,治疗前后免疫功能指标(CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+))、炎症介质[血清超敏C反应蛋白(hs-CRP)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]水平,不良反应发生情况与治疗后6个月复发情况。结果研究组临床总有效率93.75%显著高于对照组的79.17%,差异具有统计学意义(P<0.05)。研究组患者的糜烂创面愈合时间(6.06±1.34)d及白带异常消失时间(9.34±1.45)d、小腹坠胀消失时间(5.05±1.45)d均显著短于对照组的(8.78±1.55)、(11.49±1.67)、(7.76±1.82)d,差异具有统计学意义(P<0.05)。治疗前,两组患者的CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+)对比差异无统计学意义(P>0.05);治疗后,两组患者的CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)均高于本组治疗前,CD8^(+)低于本组治疗前,且研究组CD3^(+)(64.89±5.27)%、CD4^(+)(38.88±6.07)%及CD4^(+)/CD8^(+)(1.55±0.28)明显高于对照组的(56.68±5.11)%、(34.41±6.23)%、(1.39±0.22),CD8^(+)(21.11±4.89)%明显低于对照组的(26.67±4.54)%,差异具有统计学意义(P<0.05)。治疗前,两组患者的hs-CRP、IL-8、TNF-α水平对比差异无统计学意义(P>0.05);治疗后,两组患者的hs-CRP、IL-8、TNF-α水平均低于本组治疗前,且研究组hs-CRP(4.47±1.56)mg/L、IL-8(28.00±5.54)pg/ml、TNF-α(1.22±0.33)ng/L均低于对照组的(7.07±1.22)mg/L、(31.19±5.73)pg/ml、(1.45±0.38)ng/L,差异具有统计学意义(P<0.05)。研究组治疗后6个月的复发率2.08%明显低于对照组的14.58%,差异具有统计学意义(P<0.05)。两组不良反应发生率对比差异无统计学意义(P>0.05)。结论聚甲酚磺醛溶液宫颈局部用药治疗慢性子宫颈炎糜烂样改变可提高患者疗效,减轻炎症,提高免疫功能。
Objective To analyze the clinical effect of topical application of policresulen solution in the treatment of chronic cervicitis with erosive changes.Methods A total of 96 patients with chronic cervicitis with erosive changes were randomly divided into control group and research group,with 48 cases in each group.The control group was treated with levofloxacin hydrochloride+Gongyanping tablet orally,and the research group was treated with topical application of policresulen solution on the basis of the control group.Both groups were compared in terms of clinical efficacy,improvement time of clinical symptoms,immune function indexes(CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+))and levels of inflammatory mediators[serum high-sensitivity C-reactive protein(hs-CRP),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)]before and after treatment,occurrence of adverse reactions,and recurrence at 6 months after treatment.Results The total clinical effective rate of the research group was 93.75%,which was significantly higher than that of 79.17%of the control group,and the difference was statistically significant(P<0.05).The research group had healing time of erosion wound of(6.06±1.34)d,the disappearance time of leucorrhea of(9.34±1.45)d,and the disappearance time of lower abdominal distension of(5.05±1.45)d,which were significantly shorter than those of(8.78±1.55),(11.49±1.67),and(7.76±1.82)d in the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)between the two groups(P>0.05).After treatment,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the two groups were higher than those before before treatment in this group,while CD8^(+)was lower than that before treatment in this group;the research group had CD3^(+)of(64.89±5.27)%,CD4^(+)of(38.88±6.07)%and CD4^(+)/CD8^(+)of(1.55±0.28),which were significantly higher than those of(56.68±5.11)%,(34.41±6.23)%and(1.39±0.22)in the control group;CD8^(+)of(21.11±4.89)%in the research group was significantly lower than that of(26.67±4.54)%in the control group;the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the levels of hs-CRP,IL-8 and TNF-αbetween the two groups(P>0.05).After treatment,the levels of hs-CRP,IL-8 and TNF-αin the two groups were lower than those before treatment in this group;the research group had hs-CRP of(4.47±1.56)mg/L,IL-8 of(28.00±5.54)pg/ml and TNF-αof(1.22±0.33)ng/L,which were lower than those of(7.07±1.22)mg/L,(31.19±5.73)pg/ml and(1.45±0.38)ng/L in the control group;the differences were statistically significant(P<0.05).The recurrence rate at 6 months after treatment in the research group was 2.08%,which was significantly lower than that of 14.58%in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Topical application of policresulen solution for the treatment of chronic cervicitis with erosive changes can improve the efficacy,reduce inflammation and improve immune function of patients.
作者
张妍
肖玉凤
ZHANG Yan;XIAO Yu-feng(Chengwu County People's Hospital,Heze 274200,China)
出处
《中国实用医药》
2023年第9期25-28,共4页
China Practical Medicine
