摘要
Dear Editor,The optic nerve,which belongs to the central nervous system(CNS),cannot regenerate when injured in adult mammals.1 Up to now,no readily translatable measures are available for repairing a severely injured optic nerve.Herein we demonstrated that ciliary neurotrophic factor(CNTF)-chitosan enabled the reconstruction and functional recovery of the adult rat visual system,thus shedding light on the clinical potential for repairing the severely injured optic nerve.
基金
We thank for Beijing Key Laboratory of Ophthalmology and Visual Science,School of Ophthalmology,Capital Medical University for measuring F-VEP.We thank technicians in the Core Facility Center of Capital Medical University.This work was supported by the National Natural Science Foundation of China(Grants 81941011,31730030,31971279,31900749,31771053)
and Ministry of Science and Technology of China(Grants 2017YFC1104002,2017YFC1104001)
Beijing Science and Technology Program(Grant Z181100001818007)
National Natural Science Foundation of China(Grants 31650001,31320103903,31670988)
Beijing Natural Science Foundation(Grant 7214301).
