摘要
三基序蛋白家族(tripartite motif,TRIM)是参与不同细胞功能的一大类具有E3泛素连接酶活性的蛋白质,在宿主抗病毒免疫应答中发挥着重要的作用。TRIM家族蛋白可通过提高宿主固有免疫应答或直接降解病毒蛋白发挥抗病毒活性;部分病毒有时也可利用TRIM家族蛋白调控细胞因子表达促进自身感染。本文综述了TRIM家族蛋白在病毒复制中的作用及相关机制的研究进展,为研究病毒感染机制提供参考。
The tripartite motif(TRIM)protein family is composed of a variety of proteins with E3 ubiquitin ligase activity.These proteins are involved in different cell processes and play a role in the host immune response to viral infection.The proteins of TRIM family can exert antiviral activity by enhancing host innate immune response or directly degrading viral proteins.In some cases,some viruses can use TRIM family proteins to regulate cytokine expression to promote their infections.This article reviews the research progress in the role of TRIM family proteins in viral replication and the related mechanisms,aiming to provide a reference for studying the mechanism of viral infection.
作者
杨东亮
毕冬琳
杨晓莉
柏家林
李琼毅
YANG Dongliang;BI Donglin;YANG Xiaoli;BAI Jialin;LI Qiongyi(College of Life Science and Engineering,Northwest Minzu University,Lanzhou 730030,Gansu,China;Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission,Biomedical Research Center,Northwest Minzu University,Lanzhou 730030,Gansu,China)
出处
《微生物学报》
CAS
CSCD
北大核心
2023年第4期1356-1364,共9页
Acta Microbiologica Sinica
基金
国家自然科学基金(31860696,31702234)
甘肃省教育厅高等教育教学成果培育项目(2020GSJXCGPY-07)
中央高校基本科研业务费项目(31920190003)。
