摘要
椎间盘退变是一种常见的慢性退行性关节疾病。椎间盘退变的发病与髓核细胞的功能障碍或丧失密切相关。线粒体作为髓核细胞腺苷三磷酸(adenosine triphosphate,ATP)的主要来源,对维持髓核细胞生存和生理功能至关重要。线粒体自噬是近几年发现的一种重要细胞生理过程,通常被认为是线粒体质量控制的一种主要机制。大量研究显示,线粒体自噬在椎间盘退变的发生和缓解过程中均发挥重要作用。因此,该文通过综述线粒体自噬与椎间盘退变的相关文献,探究sirtuins、Parkin和缺氧诱导因子1α(hypoxia-inducible factor 1-alpha,HIF-1α)等信号分子在线粒体自噬调控椎间盘退变的过程中可能起到的关键作用,总结线粒体自噬对椎间盘退变的具体调控机制,以期为椎间盘退变潜在治疗靶点的相关研究提供参考和依据。
Intervertebral disc degeneration is a common chronic degenerative joint disease.The pathogenesis of intervertebral disc degeneration is closely related to the dysfunction or loss of nucleus pulposus cells.Mitochondria,as the main sources of ATP(adenosine triphosphate)in nucleus pulposus cells,are essential to maintain the survival and physiological functions of nucleus pulposus cells.Mitophagy was recently discovered to be an important cellular physiological process,which was considered to be a major mechanism of mitochondrial quality control.Cumulative studies have shown that mitophagy plays an important role in both the occurrence and remission of intervertebral disc degeneration.Therefore,by reviewing the literature on mitophagy and intervertebral disc degeneration,this paper explored the possible key roles of signaling molecules such as sirtuins,Parkin,and HIF-1α(hypoxia-inducible factor 1-alpha)in the regulation of intervertebral disc degeneration by mitophagy and summarized the specific regulatory mechanism of mitophagy on intervertebral disc degeneration,providing a reference and basis for the research on potential therapeutic targets for intervertebral disc degeneration.
作者
曾锦全
柯俊杰
ZENG Jinquan;KE Junjie(Professional Tennis College,Wuhan City Vocational College,Wuhan 430070,China;Sports Medicine and Health Institute,Chengdu Sport University,Chengdu 610041,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2023年第2期266-273,共8页
Chinese Journal of Cell Biology
关键词
椎间盘退变
线粒体自噬
髓核细胞
自噬
intervertebral disc degeneration
mitophagy
nucleus pulposus
autophagy
