摘要
肝纤维化是由多种病因引起的细胞外基质过度累积,导致纤维瘢痕形成的病理过程。目前,病因治疗(如有效的抗病毒治疗)仍是肝纤维化的主要治疗策略。肝巨噬细胞作为肝纤维化的核心参与者,影响肝纤维化的进展与消退,被认为是肝纤维化治疗的重要靶点。近年来,随着免疫代谢领域的进展,代谢重编程已成为决定巨噬细胞结局和推动疾病发展的关键因素。本文综述了肝纤维化过程中巨噬细胞的作用及其代谢变化,并讨论靶向巨噬细胞代谢的抗纤维化潜力,为肝纤维化的发生、发展和治疗提供新的思路.
Liver fibrosis is a pathological process of fibrous scar formation caused by excessive accumulation of extracellular matrix due to various etiologies.At present,etiological treatment,such as effective antiviral therapy,is still the main treatment strategy for liver fibrosis.As the core participant of liver fibrosis,liver macrophages affect the progression and regression of liver fibrosis and are thus considered an important target for the treatment of liver fibrosis.With the recent advances in the field of immune metabolism,metabolic reprogramming has become a key factor for determining the outcome of macrophages and promoting the development of diseases.This article reviews the role and metabolic changes of macrophages during liver fibrosis and discusses the anti-fibrotic potential of targeting macrophage metabolism,so as to provide new ideas for the development,progression,and treatment of liver fibrosis.
作者
许钧
金卫林
李汛
XU Jun;JIN Weilin;LI Xun(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,China;Medical Frontier Innovation Research Center,The First Hospital of Lanzhou University,Lanzhou 730000,China;Department of General Surgery,The First Hospital of Lanzhou University,Lanzhou 730000,China;Gansu Province Key Laboratory of Biotherapy and Regenerative Medicine,Lanzhou 730000,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2023年第4期922-928,共7页
Journal of Clinical Hepatology
基金
国家自然科学基金地区项目(82060119)。
关键词
肝硬化
巨噬细胞
治疗学
Liver Cirrhosis
Macrophages
Therapeutics
