摘要
建立了气相色谱-质谱联用法测定婴幼儿化妆品中甲基氯异噻唑啉酮等18种防腐剂含量。样品采用0.1 mg/mL的抗坏血酸甲醇溶液作为提取溶剂,采用Agilent DB-5 MS毛细管色谱柱(30 m×0.25 mm×0.25μm)进行气相分离,程序升温,分流进样进行测定,外标法定量。结果表明,在20 min内即可实现对18种防腐剂的有效分离测定,18种防腐剂质量浓度在各自范围内与峰面积呈现良好的线性关系,相关系数大于0.998,方法检出限为0.15~1.50μg/kg,在低中高3种加标浓度水平下平均回收率为76.7%~104.9%。该方法准确、灵敏、快速,适用于婴幼儿化妆品中18种防腐剂的同时测定。
A gas chromatography-mass spectrometry( GC-MS) method was established for the determination of 18 preservatives compounds( methyl chloride isothiazolinone,etc.) in infant cosmetics.The cosmetic samples were extracted with 0.1 mg/mL ascorbic acid methanol as the solvent,separated on an Agilent DB-5 MS chromatographic column( 30 m×0.25 mm×0.25 μm) by temperature programming with split injection technique,analyzed by GC-MS,and then quantified by an external standard curve.The results indicate that the effective separation and determination of 18 preservatives can be realized within 20 minutes.The method has good linear relationship with the correlation coefficients( R) greater than 0.998,the limits of detection( LOD) are in the ranges of 0.15-1.50 μg/kg,and the average recoveries at three spiked levels are in the range of 76.7%-104.9%.The method is accurate,rapid,simple,and quite suitable for the simultaneous determination of 18 preservatives in infant cosmetics.
作者
李玉丽
肖瑞娜
李亚楠
唐启奎
王启林
韩晓萍
Yuli Li;Ruina Xiao;Yanan Li;Qikui Tang;Qilin Wang;Xiaoping Han(Qinghai Key Laboratory of modernized Chinese and Tibetan Medicine Research,Qinghai Institute for Drug Control,Xining,Qinghai 810016,China;Qinghai Key Laboratory of modernized Chinese and Tibetan Medicine Research,Xining,Qinghai 810016,China)
出处
《日用化学工业（中英文）》
CAS
北大核心
2023年第3期349-354,共6页
China Surfactant Detergent & Cosmetics
关键词
气相色谱-质谱联用
婴幼儿化妆品
防腐剂
gas chromatography-mass spectrometry
infant cosmetics
preservative
