摘要
目的:探究于高危型HPV感染的宫颈上皮内瘤变患者应用冷刀锥切术的临床疗效。方法:选取医院收治的60例伴高危型HPV感染的宫颈上皮内瘤变(CIN)患者,随机分为对照组和观察组,各30例。对照组给予宫颈环形电切术(LEEP),观察组给予宫颈冷刀锥切术(CKC),对比两组患者的临床疗效。结果:观察组患者的彻底清除率与对照组差异无统计学意义(P>0.05);与对照组相比,观察组患者的手术时间、术中出血量、并发症情况等指标均存在不足,数据差异具有统计学意义(P<0.05)。观察组患者的转阴率、复发率、预后生活质量评分等指标明显优于对照组,差异有统计学意义(P<0.05)。结论:对宫颈上皮内瘤变患者行冷刀锥切术可有效清除病灶,且预后好、复发率低,但相较于宫颈环形电切除术,在术中出血量、手术时间控制上仍存有不足,故应综合考虑患者情况和两者的应用优势,最大程度提高冷刀锥切术的诊断与治疗质量。
Objective:To investigate the clinical efficacy of cold knife conization in high-risk HPV infected patients with cervical intraepithelial neoplasia.Methods:60 patients with cervical intraepithelial neoplasia with high-risk HPV infection admitted to our hospital were randomly divided into the control group and the observation group, with 30 cases in each group. The control group was given cervical loop electrosurgical excision procedure(LEEP), and the observation group was given cervical cold knife conization(CKC).The clinical effects of the two groups were compared.Results: The total clearance rate in the observation group was not significantly different from that in the control group(P>0.05). Compared with the control group, the operation time, intraoperative bleeding, complications and other indicators in the observation group were insufficient, and the data difference was significant, with statistical significance(P<0.05). The negative conversion rate, recurrence rate, prognosis quality of life score and other indicators in the observation group were significantly better than those in the control group(P<0.05).Conclusion:Cervical cold knife conization for patients with cervical intraepithelial neoplasia can effectively clear the lesions, and has good prognosis and low recurrence rate. However, compared with circular electrosurgical excision procedure, there are still shortcomings in the control of intraoperative blood loss and operation time. Therefore, it is necessary to comprehensively consider the patient’s situation and the application advantages of both to maximize the quality of diagnosis and treatment of cervical cold knife conization.
作者
马海芬
MA Hai-fen(Zhangjiakou Xuangang Hospital Obstetrics and Gynecology Department Zhangjiakou,Zhangjiakou 075000,Hebei)
出处
《安徽医专学报》
2023年第1期130-132,共3页
Journal of Anhui Medical College
关键词
冷刀锥切术
高危型HPV
宫颈
上皮内瘤变
cold knife conization
high risk HPV
cervix
intraepithelial neoplasia
