摘要
Fluorescent imaging based on near-infrared(NIR)fluorophores has revolutionized the techniques employed for detecting biological events in depth owing to their advantages referring to diminished photon scattering,high signal-to-noise ratio and better light transparence through tissue.As for conventional luminogens,the nanofabrication of those innately hydrophobicπ-conjugated architectures into water-dispersible nanoparticles(NPs)may result in attenuated fluorescent intensity deriving from the detrimental distribution ofπ-πinteractions in the confined space.Oppositely,chromophores possessing aggregation-induced emission(AIE)characteristics emit boosted brightness at aggregate level according to the mechanism of restriction of intramolecular motion(RIM).In this review,we summarize the recent progresses of NIR emissive AIE NPs for multifarious biomedical applications from the viewpoint of different fabricated manners,mainly covering self-assembly and matrices assisted approaches.Furthermore,the current challenges and future research directions of NIR AIE NPs are briefly discussed.
基金
supported by the National Natural Science Foundation of China (grant Nos.82171990,52122317,22175120)
the Developmental Fund for Science and Technology of Shenzhen government (grant Nos.RCYX20200714114525101,JCYJ20190808153415062)
the Natural Science Foundation for Distinguished Young Scholars of Guangdong Province (grant No.2020B1515020011)
Guangdong Province Key Area R&D Program (grant No.2019B110233004).The authors acknowledge the Instrumental Analysis Center of Shenzhen University.
