摘要
目的 探析老年脑梗死(CI)患者血管内皮生长因子(VEGF)、白细胞介素33(IL-33)、超敏C反应蛋白(hs-CRP)水平及其与预后的关系。方法 选择2018年1月至2020年1月于广东医科大学附属医院神经内科就诊的老年CI患者112例为CI组,根据改良Rankin(mRS)评分分为预后良好组(n=78)和预后不良组(n=34),另按同期、年龄匹配原则选择在本院体检且体检结果正常的健康者40名作为对照组。对比三组血清VEGF、IL-33、hs-CRP水平差异,采用Pearson法分析各指标与mRS评分之间的关系,绘制受试者工作特征曲线(ROC)评估VEGF、IL-33、hs-CRP对老年CI不良预后的预测价值,同时采用Logistic回归分析影响老年CI预后的危险因素。结果 三组血清VEGF、IL-33、hs-CRP水平比较:预后不良组>预后良好组>对照组,差异均有统计学意义(P<0.05)。Pearson相关性分析结果表明,血清VEGF、IL-33、hs-CRP水平与mRS评分呈负相关(P均<0.001)。ROC曲线显示,VEGF、IL-33、hs-CRP联合预测老年CI不良预后的效能更高,其曲线下面积(AUC)为0.817,灵敏度、特异度分别为94.12%、69.23%。Logistic多因素分析显示,年龄≥70岁、高脂血症史、入院时NIHSS评分≥5分及VEGF、IL-33、hs-CRP过度表达是影响老年CI不良预后的独立危险因素(P<0.05)。结论 血清VEGF、IL-33、hs-CRP水平与老年CI患者不良预后密切相关,其表达对老年CI预后具有良好的预测价值。
Objective To analyze the levels of vascular endothelial growth factor(VEGF),interleukin 33(IL-33)and high-sensitivity C-reactive protein(hs-CRP)in elderly patients with cerebral infarction(CI),and their relationship with prognosis. Methods A total of 112 elderly patients with CI treated in the Department of Neurology of the Affiliated Hospital of Guangdong Medical University were selected between January 2018 and January 2020. According to the modified Rankin(mRS)score,they were divided into a good prognosis group(n=78)and a poor prognosis group(n=34). Meanwhile,40 healthy individuals of matched age were selected as the control group. The levels of serum VEGF,IL-33 and hs-CRP were compared among the three groups. Pearson correlation analysis between the above-mentioned indicators and mRS scores were performed. The receiver operating characteristics(ROC)curve was plotted to evaluate the prognostic value of VEGF,IL-33 and hs-CRP in elderly patients with CI. Logistic analysis was performed to screen the risk factors affecting the prognosis of elderly patients with CI. Results Comparison of serum levels of VEGF,IL-33 and hsCRP among the three groups,the poor prognosis group > the good prognosis group > the control group(P<0.05). Pearson correlation analysis showed that the levels of serum VEGF,IL-33 and hs-CRP were negatively correlated with mRS scores(P<0.001). The ROC curve showed that the combination of VEGF,IL-33 and hsCRP was more effective in predicting the poor prognosis of elderly patients with CI. The area under the curve(AUC),sensitivity and specificity were 0.817,94.12% and 69.23%,respectively. Multivariate logistic analysis showed that age ≥70,history of hyperlipidemia,NIHSS score ≥ 5 at admission,and overexpression of VEGF,IL-33 and hs-CRP were independent risk factors for poor prognosis of elderly patients with CI(P<0.05).Conclusion The levels of serum VEGF,IL-33 and hs-CRP are closely related to the prognosis of elderly patients with CI,which indicates a high prognostic value of these indicators in elderly patients with CI.
作者
李嘉辉
吴显斌
王祈骅
LI Jiahui;WU Xianbin;WANG Qihua(Institute of Neurology,Affiliated Hospital of Guangdong Medical University,Guangdong Key Laboratory of Aging-related Heart and Brain Diseases,Zhanjiang,Guangdong,China,524000;Department of Enceph-alopathy,Yulin Hospital of Traditional Chinese Medicine,Yulin,Guangxi,China,537000;Department of Internal Medicine,Foshan First People's Hospital,Foshan,Guangdong,China,528000)
出处
《分子诊断与治疗杂志》
2023年第1期34-38,共5页
Journal of Molecular Diagnostics and Therapy
基金
广东省自然科学基金面上项目(2018A1515011536)。
关键词
老年
脑梗死
血管内皮生长因子
白细胞介素-33
超敏C反应蛋白
Elderly
Cerebral infarction
Vascular endothelial growth factor
Interleukin-33
High-sensitivity C-reactive protein
