摘要
糖尿病是一种代谢和内分泌紊乱性疾病,随着发病率的不断升高对人类的身体健康造成威胁。近年来皂苷类化合物因其降血糖生物活性而被广泛关注,降糖活性的调节可通过多个靶点和信号通路实现,主要包括胰岛素信号通路、基于碳水化合物的代谢途径、内质网应激调节通路、PPAR调节通路和游离脂肪酸促进胰岛素分泌以及多通路联合作用。本文着重从降糖信号通路入手,就近十年来皂苷类化合物降血糖作用及其作用机制进行综述,为皂苷类化合物降糖活性的进一步开发和应用,以及糖尿病的治疗和预防提供参考。
Diabetes is a metabolic and endocrine disorder,which poses a threat to human health with the increasing incidence of diabetes.In recent years,saponins have attracted wide attention because of their hypoglycemic activity.The regulation of hypoglycemic activity of saponins can be achieved through multiple targets and signal pathways,including insulin signaling pathway,carbohydrate-based metabolic pathway,endoplasmic reticulum stress regulatory pathway,PPAR regulatory pathway and free fatty acid promoting insulin secretion and multiple pathways.Starting with the hypoglycemic signal pathway,this article reviews the hypoglycemic effect and mechanism of saponins in recent ten years,in order to provide reference for the further development and application of hypoglycemic activity of saponins,as well as the treatment and prevention of diabetes.
作者
王月
苏蓉
刘振华
董琦
WANG Yue;SU Rong;LIU Zhen-hua;DONG Qi(Medical College of Qinghai University,Xining 810016,China;Northwest Institute of Plateau Biology,Chinese Academy of Sciences,Xining 810008,China)
出处
《天然产物研究与开发》
CAS
CSCD
2023年第1期159-170,共12页
Natural Product Research and Development
基金
2020年中国科学院西部之光项目(1.14)。
关键词
皂苷
降血糖
作用机制
信号通路
saponins
hypoglycemic
mechanism
signal pathway
