摘要
目的评价婴儿专用0.35 T脑MRI系统扫描的安全性、有效性。方法该研究为双中心、单组目标值法临床试验,前瞻性收集2020年6月至7月间苏州大学附属儿童医院和连云港市第一人民医院66例0~12个月婴儿,月龄(6.3±3.4)个月,均在婴儿专用0.35 T脑MRI系统行颅脑平扫,使用双通道收发一体头线圈。扫描方向包括横断面、矢状面和冠状面,扫描序列包括自旋回波T1WI、快速自旋回波T2WI、液体衰减反转恢复序列、扩散加权成像和三维梯度回波序列。每例受试者至少接受2个扫描方向及2个扫描序列。采用李克特5分制量表评估MRI图像质量,目标值为评分≥3分。颅脑MRI扫描前或扫描后监测婴儿体温、心率和呼吸情况,扫描过程中监测MRI系统的噪声,记录不良反应。结果5例婴儿在自然睡眠状态下完成扫描,61例经水合氯醛镇静后完成扫描。41例颅脑MRI图像质量评分为5分,21例为4分,4例为3分。3分主要是由于运动伪影所致。所有婴儿颅脑MRI扫描后生命体征平稳,心率(126.8±12.9)次/min,呼吸(38.2±6.8)次/min。47例婴儿颅脑MRI前后体温无升高,15例升高<0.3℃,4例升高0.3~0.5℃。扫描中记录的噪声为(57.5±1.8)dB(A)。1例婴儿MRI当日出现轻度腹泻,未经治疗,第2天症状消失,余无不良反应。结论婴儿专用0.35 T脑MRI系统安全性高,图像质量优良,可以有效应用于临床。
Objective To evaluate the safety and efficacy of a dedicated neonatal-infant brain 0.35 T MRI system.Methods A dual-center controlled clinical trial was conducted with single-arm objective performance criteria.From June to July 2020,sixty-six infants aged 0-12(6.3±3.4)months were recruited from Children′s Hospital of Soochow University and the First People′s Hospital of Lianyungang prospectively.All infants underwent brain MRI with a dedicated neonatal-infant 0.35 T brain MRI system,using the dedicated two-channel transceiver head coil.MRI protocol included spin echo T1WI,fast spin echo T2WI,fluid attenuated inversion recovery,diffusion weighted imaging and 3D gradient echo sequence.MRI sequences were set with three orientations(axial,sagittal and coronal).Each case received at least two scanning planes and two scanning sequences.Five-point Likert scoring system was used to evaluate the image quality of acquired images,and the target value was set as at least 3 points per image.The temperature,heart rate and breathe of the infants were recorded before and after MRI;the acoustic noise of the MRI system was measured during the scanning process;and the adverse reactions were recorded if presented.Results Five infants successfully completed their examination during non-sedated sleep in a single attempt,and 61 infants after sedation with chloral hydrate.Based on MRI-based five-point Likert scoring system,41 cases achieved a score of 5,21 cases with a score of 4 and 4 cases with a score of 3.Cases with score of 3 was due to movement of the infants during the scan,which resulted in motion related artifacts.The vital signs of all infants showed stable before and after imaging,with heart rate of(126.8±12.9)beats per minute,breathe of(38.2±6.8)times per minute.It was found that 47 cases showed no sign of temperature raise after brain MRI,15 cases had less than 0.3℃raise and 4 cases had 0.3℃to 0.5℃raise.The noise recorded during the scanning process was(57.5±1.8)dB(A).One case had mild diarrhea on the day of MR scan,and the symptoms disappeared on the second day without treatment;no adverse reactions were found for the rest subjects.Conclusion Dedicated neonatal-infant 0.35 T brain MRI system allows data acquisition with high safety and excellent image quality,which has potentials in the clinical applications.
作者
刘玉奇
贾慧惠
宋永瑞
吴继志
方林
武林
苗重昌
盛茂
Liu Yuqi;Jia Huihui;Song Yongrui;Wu Jizhi;Fang Lin;Wu Lin;Miao Chongchang;Sheng Mao(Department of Radiology,Children′s Hospital of Soochow University,Suzhou 215002,China;Department of Radiology,the First People′s Hospital of Lianyungang,Lianyungang 222002,China)
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2023年第1期73-78,共6页
Chinese Journal of Radiology
关键词
磁共振成像
婴儿
脑
Magnetic resonance imaging
Infant
Brain
