摘要
乌头汤作为治疗痹证的经典方剂,治疗类风湿关节炎(RA)已有千年历史。一系列临床研究证实,乌头汤在改善RA关节炎症、肿胀、疼痛等方面有较好的疗效。同时作为一种补充替代疗法,乌头汤与西药联合应用可以减少西药的用量,减轻西药副作用,提高现有RA治疗方案的安全性和有效性。随着对RA病理机制研究及乌头汤的药理学研究的深入,乌头汤在治疗RA方面的研究取得许多进展,尤其在抗炎、镇痛、免疫调节以及抑制血管生成等方面。该文从临床研究和实验研究两个方面对乌头汤治疗RA相关进展进行系统性综述。
As a traditional Chinese medicine compound for the treatment of rheumatoid arthritis,Wutou decoction has been used as a classic remedy for the treatment of paralysis for rheumatoid arthritis(RA)in China for thousands of years.A series of clinical studies have confirmed that Wutou decoction has a good effect on improving RA joint inflammation,swelling and pain.At the same time,as a supplementary alternative therapy,the combined application of Wutou decoction with western medicine can reduce the dosage of western medicine,reduce the side effects of western medicine,and improve the safety and effectiveness of existing RA treatment regimens.With the advancement of pharmacology research of Wutou decoction and the pathological mechanism of rheumatoid arthritis,many advances have been made in the treatment of RA,especially in anti-inflammatory,analgesic,immunomodulatory and angiogenic inhibition.This study systematically reviewed the progress of Wutou decoction in the treatment of rheumatoid arthritis from clinical research and experimental research.
作者
巴鑫
陈哲
涂胜豪
BA Xin;CHEN Zhe;TU Shenghao(Department of Integrated Traditional Chinese and Western Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)
出处
《医药导报》
CAS
北大核心
2023年第2期173-177,共5页
Herald of Medicine
基金
国家自然科学基金资助项目(81874383)。
关键词
乌头汤
类风湿关节炎
炎症
免疫调节
镇痛
血管生成
Wutou decoction
Rheumatoid arthritis
Inflammation
Immunomodulatory
Analgesia
Angiogenesis
