摘要
背景:骨质疏松症患者多伴血液黏稠性增加,属于中医学“血瘀”范畴。血液黏性增加如何影响微血管流体性能有待阐明。目的:基于计算流体力学探讨血液黏性对小血管网流体力学的影响。方法:在ANSYS 19.0软件Geometry模块构建小血管网三维模型,在Mesh模块进行体网格划分,属性设定小血管网管壁为无滑移的刚性壁,血液为层流、黏性、不可压缩的牛顿流体,设定血液密度、入口流速等物理信息,并设定多个血液黏性系数,采用Navier-Stokes(NS)方程组进行计算。分析比较不同血液黏性下,小血管网不同部位流体力学性能差异。结果与结论:(1)血液流线、血液流速、质量流量及管壁剪切力在小血管网内均呈现“U”型分布,即出、入口处大,血管网中间交接处小;随着血液黏性系数增大,小血管网各部位血液流线逐渐稀疏、血液流速逐渐降低、质量流量逐渐减少,管壁剪切力则显著增大;血管网交接处的管壁剪切力改变量百分比最大。(2)结论:血液黏性会改变小血管网内流体力学环境,其中对管壁剪切力影响最为明显。基于计算流体力学可以很好地反映血液黏性改变对血液流体力学性能的影响,为基于成血管-成骨偶联的补肾活血法防治骨质疏松症提供新的研究方法。
BACKGROUND:Patients with osteoporosis patients often present with increased blood viscosity,which belongs to the category of"blood stasis"in traditional Chinese medicine.How,the effects of increased blood viscosity on mic rovascular fluid properties remain to be elucidated.OBJECTIVE:To investigate the effect of blood viscosity on the hydrodynamics of vascular network by computational fluid dynamics.METHODS:The three-dimensional model of vascular network was constructed based on the Geometry module of ANSYS 19.0 software,and the vascular network was then meshed to tetrahedral elements in Mesh module.The vascular network was assumed to rigid wall without slip,and the blood was assumed to laminar,viscous,and incompressible Newtonian fluid.Blood density,velocity,and a series of blood viscosity coefficients we re also established.The NavierStokes equation was adopted for simulation.The effects of blood viscosity on the hydrodynamics of different parts of vascular network were analyzed.RESULTS AND CONCLUSION:The streamline,velocity,mass flow,and wall shear stress in the vascular network demonstrated a"U"shaped distribution,that is,these contents in outlet and inlet were higher than those in the junction of the vascular network.With the increase of blood viscosity,the streamline,velocity,and mass flow in each part of vascular network became sparse and dec reased slightly;however,the wall shear stress increased significantly.The largest percentage change in wall shear stress was observed at the intersection of vascular network.To conclude,blood viscosity will change the hydrodynamics of the vascular network,especially in term of wall shear stress.Computational fluid dynamics can provide a good insight into the influence of blood viscosity alteration on the hydrodynamic performance of the blood,there by providing a new research tool for the study of osteoporosis based on the coupling of angiogenesis and osteogenesis by tonifying the kidney and activating the blood circulation.
作者
郑利钦
赖厚融
代越星
何兴鹏
吴敏辉
郑德声
林梓凌
Zheng Liqin;Lai Hourong;Dai Yuexing;He Xingpeng;Wu Minhui;Zheng Desheng;Lin Ziling(The First Clinical Medical College,Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong Province,China;Laboratory of Digital Orthopedics and Biomechanics,Lingnan Medical Research Center,Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong Province,China;Department of Orthopedic Trauma,The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2023年第28期4468-4472,共5页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金(81673996),项目负责人:林梓凌。
关键词
骨质疏松症
补肾活血法
血液黏性
计算流体力学
成血管-成骨偶联
osteoporosis
tonifying the kidney and activating blood circulation
blood viscosity
computational fluid dynamics
angiogenic and osteogenic coupling
