摘要
目的 探讨和胃清凉汤治疗胃癌癌前病变(PLGC)的效果。方法 回顾性分析PLGC病人155例的临床资料,应用西药(泮托拉唑钠肠溶胶囊+铝镁二甲硅油)治疗50例,中药(和胃清凉汤)治疗52例,联合治疗(和胃清凉汤+泮托拉唑钠肠溶胶囊+铝镁二甲硅油)53例,疗程90 d。观察并比较各组中医症状、整体、肠上皮化生、胃黏膜萎缩以及异型增生疗效。结果 疗程结束后,3组病人中医症状疗效差异有显著性(H=6.49,P<0.05),中药治疗组、联合治疗组疗效均优于西药治疗组(P<0.05);3组病人整体疗效差异有显著性(H=9.62,P<0.05),中药治疗组、联合治疗组疗效均优于西药治疗组(P<0.05);3组病人肠上皮化生均明显好转(Z=-4.23~-2.02,P<0.05),中药治疗组有效率高于西药治疗组(χ^(2)=11.77,P<0.05);治疗后中药治疗组、联合治疗组病人胃黏膜萎缩均明显好转(Z=-1.91、-3.28,P<0.05),西药治疗组无明显好转(P>0.05),中药治疗组疗效明显优于西药治疗组(P<0.05);治疗后中药治疗组病人异型增生明显好转(Z=-2.34,P<0.05),联合治疗组、西药治疗组无明显好转(P>0.05),3组有效率比较差异有显著性(χ^(2)=12.00,P<0.05)。结论 和胃清凉汤能有效治疗PLGC,防止胃癌的发生。
Objective To investigate the clinical effect of Hewei Qingliang Decoction in the treatment of precancerous lesion of gastric cancer. Methods A retrospective analysis was performed for the clinical data of 155 patients with precancerous lesion of gastric cancer, among whom 50 were given Western medicine treatment(pantoprazole sodium enteric-coated capsules+aluminum-magnesium dimeticone), 52 were given traditional Chinese medicine(TCM) treatment(Hewei Qingliang Decoction), and 53 were given combined treatment(Hewei Qingliang Decoction+pantoprazole sodium enteric-coated capsules+aluminum-magne-sium dimeticone), and the course of treatment was 90 days. The above groups were compared in terms of TCM symptoms, overall treatment outcome, intestinal metaplasia, gastric mucosal atrophy, and dysplasia. Results After treatment, there was a significant difference in the treatment outcome of TCM symptoms between the three groups(H=6.49,P<0.05), and the TCM treatment group and the combined treatment group had a significantly better treatment outcome than the Western medicine treatment group(P<0.05). There was a significant difference in overall treatment outcome between the three groups(H=9.62,P<0.05), and the TCM treatment group and the combined treatment group had a significantly better overall treatment outcome than the Western medicine treatment group(P<0.05). All three groups had a significant improvement in intestinal metaplasia(Z=-4.23 to-2.02,P<0.05), and the TCM treatment group had a significantly higher response rate than the Western medicine treatment group(χ^(2)=11.77,P<0.05);the TCM treatment group and the combined treatment group had a significant improvement in gastric mucosal atrophy after treatment(Z=-1.91,-3.28;P<0.05), while there was no significant improvement in the Western medicine treatment group(P>0.05), and the TCM treatment group had a significantly better treatment outcome than the Western medicine treatment group(P<0.05);after treatment, the TCM treatment group had a significant improvement in dysplasia(Z=-2.34,P<0.05), while the combined treatment group and the Western medicine treatment group showed no significant improvement(P>0.05), and there was a significant difference in response rate between the three groups(χ^(2)=12.00,P<0.05). Conclusion Hewei Qingliang Decoction can effectively treat precancerous lesion of gastric cancer and prevent the development of gastric cancer.
作者
孙田悦
李筱媛
李玎
扈国杰
SUN Tianyue;LI Xiaoyuan;LI Ding;HU Guojie(Institute of Integrative Medicine,Qingdao University Medical College,Qingdao 266021,China)
出处
《青岛大学学报（医学版）》
CAS
2022年第6期828-831,共4页
Journal of Qingdao University(Medical Sciences)
基金
国家自然科学基金青年科学基金项目(8200-4128)
青岛市卫健委中医药科研计划课题(2020-zyy04)。
关键词
胃癌
癌前状态
中草药
和胃清凉汤
治疗结果
stomach neoplasms
precancerous conditions
drugs
Chinese herbal
Hewei Qingliang Decoction
treatment outcome
