摘要
认知功能障碍是一种由多种因素相互作用引起的慢性神经系统疾病,对患者和周围社会造成极大危害。认知功能障碍的致病因素复杂多样,包括人口学因素、遗传学因素、生活方式及个人史等。随着社会和经济压力的不断增大,应激性认知功能障碍逐渐引起关注,而同型半胱氨酸(Hcy)作为认知功能障碍的独立危险因素,也已引起医学界极大兴趣。该文回顾了慢性应激致Hcy升高的研究进展,总结了慢性应激和Hcy损伤认知功能的生物学机制,以此探讨其在应激诱导认知功能障碍中的可能作用,为应激性认知功能障碍的预防与干预提供参考。
Cognitive dysfunction is a chronic neurological disease caused by complex interactions between a wide range of factors,causing great harm to patients and the surrounding community. The pathogenesis of cognitive dysfunction is complicated and diverse,including demographic factors,genetic factors,lifestyle and personal history. With the increase in social and economic stresses,stress-induced cognitive impairment has gradually attracted more attention. Homocysteine(Hcy),as an independent risk factor for cognitive dysfunction,has become of great interest in the medical community.This review traces the research progress in chronic stress-induced Hcy elevation and summarizes the biological mechanisms of chronic stress and Hcy impairment of cognitive function in order to explore the possible role of Hcy in stress-induced cognitive dysfunction and to provide reference for the prevention of and intervention in stress-related cognitive dysfunction.
作者
李峰
王颖
王雪
赵云
谢方
钱令嘉
LI Feng;WANG Ying;WANG Xue;ZHAO Yun;XIEFang;QIAN Ling-jia(Institute of Military Cognition and Brain Sciences,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China)
出处
《军事医学》
CAS
2022年第11期867-871,共5页
Military Medical Sciences
基金
国家自然科学基金(31771290,81702454)
全军后勤科研计划重点项目(BWS17J027)。
