摘要
矿物药是中医药特色和优势的组成,蕴含独特的科学内涵。朱砂为中药制剂中的特色药味,尤以传统儿科用中药制剂为甚。因其含有汞导致不良反应,朱砂的安全性和应用备受关注。为了探讨含朱砂儿科制剂的应用规律与价值,该研究系统统计分析了《中国药典》2020年版收载的32种含朱砂的儿科制剂及《中医方剂大辞典精选本》(上、下册)中105首含朱砂的儿科方剂的应用特点及方剂的配伍关联规则,统计结果显示含朱砂儿科制剂及方剂对小儿惊风治疗上具有较大优势,但在剂型、剂量及质量控制上还存在较大问题。该研究进一步采用ICP-MS及LC-AFS测定15种常见市售含朱砂儿科制剂的总汞及可溶性汞含量。测定结果显示,样品制剂中总汞含量都远高于可溶性汞含量,且二者之间无明显关联。基于统计分析与测定结果,提出朱砂研究与应用的解决策略,以期为朱砂在儿科制剂中的合理应用提供参考。
Mineral medicine is a characteristic element of advantage of traditional Chinese medicine(TCM), which embodies unique scientific connotation. Cinnabaris is a characteristic drug in Chinese medicinal preparations, especially in Chinese medicinal pediatric preparations. Because of the adverse reactions caused by mercury contained, the safety and application of Cinnabaris have attracted much attention. To explore the application regularity and the value of the pediatric preparations containing Cinnabaris, this study statistically analyzed 32 Cinnabaris-contained pediatric preparations in the 2020 edition of the Chinese Pharmacopoeia and 105 pediatric preparations containing Cinnabaris in the Dictionary of Traditional Chinese Medicine Prescriptions(Vol. Ⅰ and Ⅱ). The statistical results indicated that the pediatric preparations and formulae containing Cinnabaris had great advantages in the treatment of pediatric convulsions, but there were still problems in dosage form, dosage, and quality control. In this study, ICP-MS and LC-AFS were further used to determine the content of total mercury and soluble mercury in 15 commercially available pediatric preparations containing Cinnabaris. It was found that the total mercury content was far higher than soluble mercury content in the sample preparations, and there was no obvious correlation between them. According to the results, the research and application strategies of Cinnabaris were put forward in order to provide references for the rational application of Cinnabaris in pediatric preparations.
作者
汪文芳
卢虹妃
朱毛毛
杨艳君
封亮
贾晓斌
WANG Wen-fang;LU Hong-fei;ZHU Mao-mao;YANG Yan-jun;FENG Liang;JIA Xiao-bin(School of Traditional Chinese Pharmacy,China Pharrmaceutical University,Nanjing 211198,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2022年第21期5765-5774,共10页
China Journal of Chinese Materia Medica
基金
国家重点研发计划“中药现代化”专项(2018YFC1706900)
中国药科大学双一流创新团队项目(CPU2018GY11)
天然药物活性组分与药效国家重点实验室项目(SKLNMZZ202025)
江苏省科技成果转化专项(BA2020077)。
关键词
朱砂
儿科制剂
数据挖掘
汞
Cinnabaris
pediatric preparations
data mining
mercury
